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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：药物化学. 药物工程
办公地点：G302
联系方式：13504248501
电子邮箱：yueqingli@dlut.edu.cn
Biomimetic synthesis of bis-alpha-substituent pyrrolidine alkaloids based on a proposed biosynthetic pathway
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论文类型：期刊论文
发表时间：2016-05-25
发表刊物：TETRAHEDRON LETTERS
收录刊物：SCIE、Scopus
卷号：57
期号：21
页面范围：2219-2221
ISSN号：0040-4039
关键字：Bis-alpha-substituent pyrrolidine alkaloids; Pyrroloxazine alkaloids; Pyrrolozoxazine; Biosynthetic pathway
摘要：A possible biosynthetic pathway of bis-alpha-substituent pyrrolidine alkaloids was proposed. Based on the proposed biosynthetic pathway, six pyrrolozoxazine alkaloids and one N-alkyl-5-hydroxymethyl-pyr-role-2-carbaldehyde alkaloid were synthesized. In a mixture of acetic acid and triethylamine, condensation of n-fructose and D-amino acids produced pyrrolozoxazine alkaloids. Replacing D-amino acids with tyramine can afford pyrrolezanthine a N-alkyl-5-hydroxymethyl-pyr-role-2-carbaldehyde alkaloid. (C) 2016 Published by Elsevier Ltd.