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个人信息Personal Information
副教授
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：药物化学. 药物工程
办公地点：G302
联系方式：13504248501
电子邮箱：yueqingli@dlut.edu.cn
Evaluation for in vitro Photodynamic Activity of Chlorin e(6)-Artesunate Conjugates by Irradiation with Different Wavelengths of Light Source
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论文类型：期刊论文
发表时间：2018-01-01
发表刊物：MACROHETEROCYCLES
收录刊物：SCIE
卷号：11
期号：4
页面范围：378-382
ISSN号：1998-9539
关键字：Photodynamic therapy; chlorin e(6); artesunate; reactive oxygen species; pholoexcitation
摘要：In the development of new photosensitizers jar cancer therapy, increasing the capacity of intracellular reactive oxygen species (ROS) production is an important strategy. In this paper, artesunate as a ROS generation group was regioselectively introduced to the chlorin e(6) scaffold to obtain four conjugates of chlorin e(6) and artesunate. By irradiation with 440 nm, 630 nm and 660 nm of light source the four conjugates exhibited significantly improved phototoxicity against HepG2 cells compared with chlorin e(6) and artesunate. Irradiation with 440 nm or 660 nm light source gave higher phototoxicity as well as intracellular ROS level.