点击次数：

论文类型：期刊论文

发表时间：2018-01-01

发表刊物：The Journal of organic chemistry

收录刊物：PubMed、SCIE

卷号：83

期号：11

页面范围：6210-6216

ISSN号：1520-6904

摘要：A rhodium-catalyzed highly regio- and stereoselective intermolecular hydrosilylation of internal ynamides has been developed. With the neutral rhodium complex [Rh(CO)2Cl]2 as a catalyst and the bulky silanes as reactants, various ynamides underwent hydrosilylation smoothly at room temperature with an excellent beta-regioselectivity and anti-stereoselectivity. The synthetically versatile beta-silyl ( Z)-enamide products could be further transformed to diverse useful building blocks. Several possible mechanisms are proposed to rationalize this unique formal trans-addition-type selectivity.