|
个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：吉林大学
学位：博士
所在单位：化工学院
学科：高分子材料. 高分子化学与物理
办公地点：西部校区化工实验楼A207
联系方式：13052731242
电子邮箱：zyb1104@dlut.edu.cn
Iridium-Catalyzed Highly Regioselective and Diastereoselective Allylic Etherification To Access cis-2,6-Disubstituted Dihydropyridinones
点击次数：
论文类型：期刊论文
发表时间：2018-10-19
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：PubMed、SCIE
卷号：83
期号：20
页面范围：12822-12830
ISSN号：0022-3263
摘要：A highly regio- and diastereoselective method to access cis-2,6-disubstituted dihydropyridinones under mild conditions by an iridium-catalyzed allylic etherification is reported. cis-2,6-Disubstituted dihydropyridinones are important precursors for the de novo synthesis of the corresponding piperidine alkaloids and iminosugars. This strategy features a broad substrate scope, high yields, and excellent regio- and diastereoselectivities. A pi-allyl-Ir intermediate is involved in the mechanism. The strong A(1,3)-strain from the tosyl group may also favor the formation of cis-products in this transformation.