点击次数：

论文类型：期刊论文

发表时间：2019-03-14

发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY

收录刊物：PubMed、EI、SCIE

卷号：17

期号：10

页面范围：2663-2669

ISSN号：1477-0520

摘要：A method to access various multisubstituted indoles from propargylic alcohols and readily available enol nucleophiles by copper-catalyzed tandem annulation/enol nucleophilic addition has been developed. Compared to the expensive metal catalysts such as platinum, gold, silver, and palladium used previously, the most economical copper(I) catalyst could achieve this reaction efficiently. The fused heterocyclic compounds, pyrrolo[1,2-a] indoles, could be afforded by further transformation of the products. The allyl cation intermediate may be involved in the mechanism.