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论文类型：期刊论文

发表时间：2006-08-01

发表刊物：CHINESE CHEMICAL LETTERS

收录刊物：SCIE、ISTIC、Scopus

卷号：17

期号：8

页面范围：1125-1128

ISSN号：1001-8417

关键字：lactic acid; 4-hydroxyproline; polyethylene glycol

摘要：A series of poly(lactic acid-4-hydroxyproline-polyethylene glycol) (PLA-Hpr-PEG) copolymers were synthesized by direct melt copolymerization of D,L-lactic acid and 4-hydroxyproline with different feed amount of polyethylene glycol (PEG) 0.1%, 0.5%, 1% and 5%, respectively. The properties of these copolymers were characterized by using IR spectroscopy, proton nuclear magnetic resonance (H-1-NMR) spectroscopy, gel permeation chromatography (GPC), X-ray diffraction and differential scaning calorimetry (DSC). PLA-Hpr-PEG are amorphous copolymers. Copolymers showed increasing water uptake capacity with increasing PEG percentage in the feed, which result in an increasing degradable rate in phosphate buffer solution (pH 7.4) at 37 degrees C.