对微观和宇宙的深入研究不仅具有相同的重要性，还具有惊人的相似性。当我们迈向星辰大海时，也不应忽视分子、电子、光子的运动规律，这些微观尺度的物质过程构成了宏观性质的基础。为了解决微观分子尺度上事件和过程的观察问题，可通过化学、光学、计算机及数学等学科的交叉，以光镜为手段，以染料分子设计和核，实现对分子互作、分布等微观事件分析，以超高时空分辨率解析荧光信息，推进超微结构尺度细胞生命过程研究，推动医疗分子诊断手段发展。

叶智伟，本科就读于大连理工大学应用化学（精细化工）专业，2011年获得保送本校研究生资格，博士期间师从大连理工大学肖义教授。研究方向为超高时空分辨成像荧光染料，至今在JACS，Angew. Chem., Int. Ed., Anal. Chem.等顶级期刊发表论文13篇，其中以第一作者（包括共一）及通讯作者发表13篇(JCR一区11篇，二区2篇)，累计他引（Google Scholar引用）>400次，单篇引用最高>100次，申请（授权）专利3项；主持国家自然科学基金面上项目，中国博士后科学基金博新计划，国家自然科学基金青年项目，中国博士后科学基金面上项目。受邀参加6th International Conference on Molecular Sensors and Molecular Logic Gates会议并作报告，担任Nature Communications审稿人。

现担任博士研究生和硕士研究生导师，具有招生资格。每年可招收博士生1人，硕士生1-2人，欢迎联络。

更多研究细节请访问课题组网站：https://yezhiwei90.github.io

（一）主持项目

1.基于超分辨成像的生物膜分子诊断探针开发，国家自然科学基金面上项目，2024.01-2027.12, 50万。

2.超分辨成像荧光染料研制，中国博士后科学基金会博新计划，2020.06-2022.06, 63万。

3.超分辨成像罗丹明染料开发，国家自然科学基金青年项目, 2021.01-2023.12, 24万。

4.多色单分子定位超分辨成像荧光染料研制，中国博士后科学基金面上项目, 8万。

（二）代表论著

1. Ye Zhiwei,# Yang Wei,#* Wang Chao,# Zheng Ying,# Chi Weijie, Liu Xiaogang,* Huang Zhenlong, Li Xiaoyuan, Xiao Yi.* Quaternary Piperazine-Substituted Rhodamines with Enhanced Brightness for Super-Resolution Imaging. Journal of the American Chemical Society, 2019,141(37):14491–14495. IF: 15(15.1), JCR: Q1(CHEMISTRY, MULTIDISCIPLINARY)

2. Ye Zhiwei,# Yu Haibo,#* Yang Wei,# Zheng Ying,# Li Ning, Bian Hui, Wang Zechen, Liu Qiang, Song Youtao, Zhang Mingyan, Xiao Yi.* Strategy to Lengthen the On-Time of Photochromic Rhodamine Spirolactam for Super-Resolution Photoactivated Localization Microscopy. Journal of the American Chemical Society, 2019,141(16):6527–6536. IF: 15(15.1), JCR: Q1(CHEMISTRY, MULTIDISCIPLINARY)

3. Ye Zhiwei,# Yang Wei,#* Zheng Ying, Wang Shujing, Zhang Xiaodong, Yu Haibo, Li Shuangshuang, Luo Chunxiong,* Peng Xiaojun,* Xiao Yi.* Integrating a Far-Red Fluorescent Probe with a Microfluidic Platform for Super-Resolution Imaging of Live Erythrocyte Membrane Dynamics. Angewandte Chemie International Edition, 2022,61(45):e202211540. IF: 16.6(15.3), JCR:Q1(CHEMISTRY, MULTIDISCIPLINARY)

4. Zheng Ying,# Ye Zhiwei,#,*(共一，共通讯) Zhang Xue, Xiao Yi.* Recruiting Rate Determines the Blinking Propensity of Rhodamine Fluorophores for Super-Resolution Imaging. Journal of the American Chemical Society, 2023,145(9):5125–5133. IF: 15(15.1), JCR: Q1(CHEMISTRY, MULTIDISCIPLINARY)

5. Ye Zhiwei, Zheng Ying, Peng Xiaojun, Xiao Yi.* Surpassing the Background Barrier for Multidimensional Single-Molecule Localization Super-Resolution Imaging: A Case of Lysosome-Exclusively Turn-on Probe. Analytical Chemistry, 2022, 94(22): 7990–7995. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

6. Zheng Ying,# Ye Zhiwei,#*(共一) Liu Zengjin, Yang Wei, Zhang Xinfu, Yang Youjun,* Xiao Yi.* Nitroso-Caged Rhodamine: A Superior Green Light-Activatable Fluorophore for Single-Molecule Localization Super-Resolution Imaging. Analytical Chemistry, 2021, 93(22):7833–7842. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

7. Zheng Ying,# Ye Zhiwei,#,*(共一，共通讯) Xiao Yi.* Subtle Structural Translation Magically Modulates the Super-Resolution Imaging of Self-Blinking Rhodamines, Analytical Chemistry, 2023,95(8):4172–4179. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

8. He Haihong,# Ye Zhiwei,#(共一) Xiao Yi,* Yang Wei,* Qian Xuhong,* Yang Youjun.*Super-Resolution Monitoring of Mitochondrial Dynamics upon Time-Gated Photo-Triggered Release of Nitric Oxide. Analytical Chemistry, 2018,90(3):2164–2169. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

9. He Haihong,# Ye Zhiwei,#(共一) Zheng Ying, Xu Xiu, Guo Chunlei, Xiao Yi,* Yang Wei,* Qian Xuhong,* Yang Youjun.* Super-Resolution Imaging of Lysosomes with a Nitroso-Caged Rhodamine. Chemical Communications, 2018,54(23): 2842–2845. IF: 4.9(4.9), JCR: Q2(CHEMISTRY, MULTIDISCIPLINARY)

10. Man Huizi,# Bian Hui,# Zhang Xinfu,* Wang Chao, Huang Zhenlong, Yan Yu, Ye Zhiwei,*(共通讯) Xiao Yi.* Hybrid labeling system for dSTORM imaging of endoplasmic reticulum for uncovering ultrastructural transformations under stress conditions. Biosensors and Bioelectronics, 2021,189:113378. IF: 12.6(10.8), JCR: Q1(BIOPHYSICS; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; CHEMISTRY, ANALYTICAL; ELECTROCHEMISTRY; NANOSCIENCE & NANOTECHNOLOGY)

11. Man Huizi, Zhou Lin, Zhu Guanghao, Zheng Ying, Ye Zhiwei,*(共通讯) Huang Zhenlong, Teng Xinru, Ai Chunzhi, Ge Guangbo,* Xiao Yi*. Super-Resolution Imaging of Autophagy by a Preferred Pair of Self-Labeling Protein Tags and Fluorescent Ligands. Analytical Chemistry, 2022, 94(43): 15057-15066. IF: 7.4(7), JCR: Q1(CHEMISTRY, ANALYTICAL)

12. Zhang Xiaodong,# Ye Zhiwei, (共一)# Zhang Xinfu,* Man Huizi, Huang Zhenlong, Li Ning, Xiao Yi.* A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA. Chemical Communications, 2019,55(13):1951–1954. IF: 4.9(4.9), JCR: Q2(CHEMISTRY, MULTIDISCIPLINARY)