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个人信息Personal Information
教授
博士生导师
硕士生导师
主要任职：Director, State Key laboratory of Fine Chemicals
其他任职：精细化工国家重点实验室主任、国务院学科评议组成员
性别：男
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 化学生物学
办公地点：大连理工大学精细化工国家重点实验室
西部校区化工实验楼F-202#
http://peng-group.dlut.edu.cn/
联系方式：大连理工大学精细化工国家重点实验室 西部校区化工实验楼F-202 辽宁省大连市高新区凌工路2号，大连116024 Tel: 0411-84986306; Fax: 0411-84986292；课题组网址：http://peng-group.dlut.edu.cn/
电子邮箱：pengxj@dlut.edu.cn
Lysozyme-targeted ratiometric fluorescent probe for SO2 in living cells
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论文类型：期刊论文
发表时间：2021-04-12
发表刊物：DYES AND PIGMENTS
卷号：180
ISSN号：0143-7208
关键字：Ratiometric; Fluorescent probe; SO2; Environmental pollutant; Lysosomes; Cell imaging
摘要：Sulfur dioxide (SO2) as a common environmental pollutant, participates in a variety of physiology and pathological processes in vivo. Lysosomes are considered to be cleaners of living cells and play a vital role in the process of metabolism. Exposure to excess SO2 will result in the increase risk of lysosomal dysfunction and induce multiple diseases. Herein a smart fluorescent probe LYSO-SO2 is developed, which achieved the ratio (F-561 nm/F-634 nm) identification of SO2 in vitro. LYSO-SO2 showed high sensitivity (detection limit 15.8 nM), rapidly response (within 5 s), and excellent selectivity. Additionally, this probe LYSO-SO2 has been successfully applied to the ratio monitoring SO2 in lysosomes which may provide an effective quantitative method for studying the physiological and pathological functions of SO2 in living cells.