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Evaluation for in vitro Photodynamic Activity of Chlorin e(6)-Artesunate Conjugates by Irradiation with Different Wavelengths of Light Source

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Indexed by:Journal Papers

Date of Publication:2018-01-01

Journal:MACROHETEROCYCLES

Included Journals:SCIE

Volume:11

Issue:4

Page Number:378-382

ISSN No.:1998-9539

Key Words:Photodynamic therapy; chlorin e(6); artesunate; reactive oxygen species; pholoexcitation

Abstract:In the development of new photosensitizers jar cancer therapy, increasing the capacity of intracellular reactive oxygen species (ROS) production is an important strategy. In this paper, artesunate as a ROS generation group was regioselectively introduced to the chlorin e(6) scaffold to obtain four conjugates of chlorin e(6) and artesunate. By irradiation with 440 nm, 630 nm and 660 nm of light source the four conjugates exhibited significantly improved phototoxicity against HepG2 cells compared with chlorin e(6) and artesunate. Irradiation with 440 nm or 660 nm light source gave higher phototoxicity as well as intracellular ROS level.

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