刘猛

基本信息Personal Information

教授 博士生导师 硕士生导师

性别 : 男

出生年月 : 1985-01-21

毕业院校 : 邹平一中

在职信息 : 在职

所在单位 : 环境学院

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个人简介Personal Profile

针对环境科学、生命科学和临床诊治中一系列分析测试的关键科学问题,近年来开展了以功能核酸(如适配体,脱氧核酶和适体核酶)为核心的化学与生物传感研究工作,主要围绕环境污染物的实时监控、传染性疾病的早期预警和癌症等重要疾病的早期诊断,重点从生物分子识别基础、传感信号放大机制、生物传感界面构建以及传感检测技术等方面入手,在生物分析、信号放大、生物分子的设计与界面组装和功能器件的构建等领域取得重要成果,实现了若干环境污染物、疾病标志物和致病菌的高灵敏、廉价、快速和实时检测。

截止目前,已在相关领域重要期刊如Nature Communications (1), Angewandte Chemie International Edition (4), ACS Nano (2), Environmental Science & Technology (1)等发表SCI检索论文27篇,其中以第一作者发表SCI 检索论文18篇,SCI他引600余次,申请美国专利6项。同时在博士后期间与多家诊断技术公司(如Pro-Lab Diagnostics)合作研发功能核酸应用技术,致力于推动其实际应用和产业化转化。

已发表论文



(1)    Meng Liu, Qiang Zhang, Zhongping Li, Jimmy Gu, John D. Brennan,* and Yingfu Li.*. Programming a topologically constrained DNA nanostructure into a sensor. Nat. Commun. 2016, 7, 12074. SCI收录. 影响因子: 11.329

(2)    Meng Liu, Christy Y. Hui, Qiang Zhang, Jimmy Gu, Balamurali Kannan, Sana Jahanshahi-Anbuhi, Carlos D. M. Filipe, John D. Brennan,* and Yingfu Li*. Target-induced and equipment-free DNA amplification with a simple paper device. Angew. Chem. Int. Ed. 2016, 55, 2709-2713 (Very Important Paper. Featured as front cover). SCI收录. 影响因子: 11.709

(3)    Meng Liu, Wenqing Zhang, Qiang Zhang, John D. Brennan,* and Yingfu Li.* Biosensing via tandem reactions of structure switching, nucleolytic digestion and DNA amplification of a DNA assembly. Angew. Chem. Int. Ed. 2015, 54, 9637-9641. SCI收录. 影响因子: 11.709

(4)    Meng Liu, Qiang Zhang, Dingran Chang, Jimmy Gu, John D. Brennan*, and Yingfu Li*. A DNAzyme feedback amplification strategy for biosensing. Angew. Chem. Int. Ed. 2017, DOI: 10.1002/ange.201700054R2.影响因子: 11.709

(5)    Meng Liu, Wenqing Zhang, Dingran Chang, Qiang Zhang, John D. Brennan,* Yingfu Li.* Integrating graphene oxide, functional DNA and nucleic acid-manipulating strategies for amplified biosensing. Trends Anal. Chem. 2015, 74, 120-129. SCI收录. 影响因子: 7.487

(6)    Meng Liu, Jinping Song, Shaomin Shuang, Chuan Dong, John D. Brennan, and Yingfu Li.* A graphene-based biosensing platform based on the release of DNA probes and rolling circle amplification. ACS Nano. 2014, 8, 5564-5573. SCI收录. 影响因子: 13.334

(7)    Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, and Xie Quan.* Interface engineering of catalytic graphene for smart colorimetric biosensing. ACS Nano 2012, 6, 3142-3151. SCI收录. 影响因子: 13.334

(8)    Meng Liu, Huimin Zhao, Shuo Chen, Hongtao Yu, and Xie Quan.* Colloidal graphene as a transducer in homogeneous fluorescence-based immunosensor for rapid and sensitive analysis of microcystin-LR. Environ. Sci. Technol. 2012, 46, 12567-12574. SCI收录. 影响因子: 5.393

(9)    Meng Liu, Qiang Zhang, Huimin Zhao,* Shuo Chen, Hongtao Yu, Yaobin Zhang and Xie Quan.* Controllable oxidative DNA cleavage-dependent regulation of graphene/DNA interaction. Chem. Commun. 2011, 47, 4084-4086 (Inside Cover). SCI收录. 影响因子: 6.567

(10)Meng Liu, Huimin Zhao, Xie Quan,* Shuo Chen and Hongtao Yu. Signal amplification via cation exchange reaction: an example in the ratiometric fluorescence probe for ultrasensitive and selective sensing of Cu(II). Chem. Commun. 2010, 46, 1144-1146. SCI收录. 影响因子: 6.567

(11)Meng Liu, Huimin Zhao, Xie Quan,* Shuo Chen and Xinfei Fan. Distance-independent quenching of quantum dots by nanoscale-graphene in self-assembled sandwich immunoassay. Chem. Commun. 2010, 46, 7909-7911. SCI收录. 影响因子: 6.567

(12)Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, Yaobin Zhang and Xie Quan.* Label-free fluorescent detection of Cu(II) ions based on DNA cleavage-dependent graphene-quenched DNAzymes. Chem. Commun. 2011, 47, 7749-7751. SCI收录. 影响因子: 6.567

(13)Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, Yaobin Zhang and Xie Quan.* A “turn-on” fluorescent copper biosensor based on DNA cleavage-dependent graphene-quenched DNAzyme. Biosens. Bioelectron. 2011, 26, 4111-4116. SCI收录. 影响因子: 7.476

(14)Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, Yaobin Zhang and Xie Quan. A graphene-based platform for single nucleotide polymorphism (SNP) Genotyping. Biosens. Bioelectron. 2011, 26, 4213-4216. SCI收录. 影响因子: 7.476

(15)Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, and Xie Quan.* Salt-controlled assembly of stacked-graphene for capturing fluorescence and its application in chemical genotoxicity screening. J. Mater. Chem. 2011, 21, 15266-15272. SCI收录. 影响因子: 6.626

(16)Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, and Xie Quan.* Capture of double-stranded DNA in stacked-graphene: giving new insight into the graphene/DNA interaction. Chem. Commun. 2012, 48, 564-566. SCI收录. 影响因子: 6.567

(17)Meng Liu, Huimin Zhao,* Shuo Chen, Hongtao Yu, and Xie Quan.* Stimuli-responsive peroxidase mimicking at a smart graphene interface. Chem. Commun. 2012, 48, 7055-7057. SCI收录. 影响因子: 6.567

(18)Meng Liu, Huimin Zhao,* Shuo Chen, Hua Wang, and Xie Quan.* Photochemical synthesis of highly fluorescent CdTe quantum dots for "on-off-on" detection of Cu(II) ions. Inorg. Chim. Acta 2012, 392, 236-240. SCI收录. 影响因子: 1.918

(19)Sana Jahanshahi-Anbuhi, Balamurali Kannan, Vincent Leung, Kevin Pennings, Meng Liu, Carmen Carrasquilla, Dawn White, Yingfu Li, Robert H. Pelton, John D. Brennan*, and Carlos D. M. Filipe*. Simple and ultrastable all-inclusive pullulan tablets for challenging bioassays. Chem. Sci. 2016, 7, 2342-2346. SCI收录. 影响因子: 9.144

(20)Yu Mao, Meng Liu, Kha Tram, Jimmy Gu, Bruno J. Salena, Yuyang Jiang,* and Yingfu Li*. Optimal DNA templates for rolling circle amplification revealed by In vitro selection. Chem. Euro J. 2015, 21, 8069-8074. SCI收录. 影响因子: 5.771

(21)Jinping Song, Pui Sai Lau, Meng Liu, Shaomin Shuang, Chuan Dong, and Yingfu Li*. A general strategy to create RNA aptamer sensors using “regulated” graphene oxide adsorption. ACS Appl. Mater. Interfaces. 2014, 6, 21806-21812. SCI收录. 影响因子: 7.145

(22)Junping Tian, Huimin Zhao*, Meng Liu, Yaqiong Chen, Xie Quan. Detection of influenza A virus based on fluorescence resonance energy transfer from quantum dots to carbon nanotubes. Anal. Chem. Acta. 2012, 723, 83-87. SCI收录. 影响因子: 4.712

(23)Sana Jahanshahi-Anbuhi, Kevin Pennings, Vincent Leung, Meng Liu, Carmen Carrasquilla, Balamurali Kannan, Yingfu Li, Robert Pelton, John D. Brennan,* and Carlos D. M. Filipe.* Pullulan encapsulation of labile biomolecules to give stable bioassay tablets. Angew. Chem. Int. Ed. 2014, 53, 6155-6158. SCI收录. 影响因子: 11.709

(24)Qiang Zhang, Yuanyuan Qu*, Meng Liu, Xinliang Li, Jiti Zhou, Xuwang Zhang, and Hao Zhou. Quantum dot-extradiol dioxygenase hybrids for highly sensitive sensing of catechol and dihydroxybiphenyl. Sens. Actuators B, 2012, 173, 477-482. SCI收录. 影响因子: 4.758

(25)Huimin Zhao,* Yangyang Chang, Meng Liu, Sheng Gao, Hongtao Yu, and Xie Quan. A universal immunosensing strategy based on regulation of the interaction between graphene and graphene quantum dots. Chem. Commun. 2013, 49, 234-236. SCI收录. 影响因子: 6.567

(26)Huimin Zhao,* Sheng Gao, Meng Liu, Yangyang Chang, Xinfei Fan, and Xie Quan. Fluorescent assay for oxytetracycline based on a long-chain aptamer assembled onto reduced graphene oxide. Microchim. Acta. 2013, 180, 829-835. SCI收录. 影响因子: 4.831

(27)Fang Yuan, Huimin Zhao*, Meng Liu, and Xie Quan. Visible assay for glycosylase based on intrinsic catalytic ability of graphene/gold nanoparticles hybrids. Biosens. Bioelectron. 2015, 68, 7-13. SCI收录, 影响因子: 7.476




 

已申请的专利



(1)       Yingfu Li, John Brennan, Meng Liu, Biosensors based on tandem reactions of structure-switching, nucleolytic digestion and DNA amplification of a DNA assembly. US Prov No. 62/182,711 was filed on June 22, 2015.

(2)       Yingfu Li, John Brennan, Meng Liu, DNA amplification device. US Prov No. 62/266,225 was filed on December 11, 2015.

(3)       Yingfu Li, John Brennan, Meng Liu, DNA nanostructure sensor. US Prov No. 62/266,207 was filed on December 11, 2015.

(4)       Yingfu Li, John Brennan, Meng Liu, Reduced graphene oxide-based biosensors. US Patent Application No. 15/091,778 was filed on April 6, 2016.

(5)       Yingfu Li, John Brennan, Meng Liu, A biosensor platform. US Prov No. 62/002,980 was filed on May 6, 2014.

(6)       Yingfu Li, John Brennan, Meng Liu, DNA templates for rolling circle amplification. US Prov No. 62/143,256 was filed on April 6, 2015.

  • 教育经历Education Background
  • 工作经历Work Experience
  • 研究方向Research Focus
  • 社会兼职Social Affiliations
  • 功能核酸;分子识别与探针;生物传感;纸基微流控器件