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Indexed by:Journal Papers
Date of Publication:2019-01-01
Journal:MACROHETEROCYCLES
Included Journals:SCIE
Volume:12
Issue:2
Page Number:187-192
ISSN No.:1998-9539
Key Words:Pyropheophorbide a; dimer; FRET; cis-aconitic anhydride; phototoxicity; PDT
Abstract:Targeting tumor acidic microenvironment, a cis-aconitate linked pyropheophorbide a dimer 3 was designed and prepared The observed fluorescence quenching of 3 verified our FRET based molecular design. Acid-dependent cleavage in aqueous solution, singlet oxygen generation, and cytotoxiciry against HepG2 cell lines of dimer 3 were investigated. The dimer demonstrated different levels of fluorescence recovery when incubated in acidic aqueous environment as well as effective phototoxicity against HepG2 cells.
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