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论文类型：期刊论文

发表时间：2018-11-10

发表刊物：SENSORS AND ACTUATORS B-CHEMICAL

收录刊物：SCIE、Scopus

卷号：273

页面范围：899-905

ISSN号：0925-4005

关键字：Mitochondria-targeted; Colorimetric; Imaging; Fluorescence; Environment detection; Sulfur dioxide

摘要：Sulfur dioxide (SO2), one of active sulfur species (ASS), plays important roles in various physiologies and pathological processes. Hence, it is urgent to monitor the fluctuation of mitochondrial SO2 in vivo. In this work, a novel mitochondria-targeting probe CZ was designed and synthesized based on carbazole derivative, which showed that probe was employed to the detection of SO2 with high selectivity, rapid response as well as naked eyes. Besides, an excellent linear relationship (R-2 = 0.9977) was observed and the detection limit was calculated as low as 0.50411M (3 sigma/k). Surprisingly, with addition of SO2 derivative, fluorescence intensity ratios (F-475 nm/F-607 nm) of probe CZ increased by 1104-fold ranging from 0.007 to 7.73. Owing to its biocompatibility, probe CZ was also successfully employed for monitoring of mitochondrial SO2 by fluorescence confocal microscopy.