Changying Xue, Professor, Department of Bioengineering, Dalian University of Technology

EDUCATION/RESEARCH EXPERIENCE

Professor, School of Life Science and Biotechnology, Dalian University of Technology, 2016-present

Research Associate, University of California-Los Angeles, Department of Bioengineering, 2012-2015

Postdoctoral Researcher, University of Illinois at Urbana-Champaign, Department of Chemical & Biomolecular Engineering,

                                         2009-2012

Ph.D., National University of Singapore, Department of Chemical & Biomolecular Engineering, 2009

M.S., Dalian University of Technology, Department of Chemical Engineering, 2005

B.S., Dalian University of Technology, Department of Chemical Engineering, 2002   

RESEARCH INTERESTS

The overall research goal is to design, synthesize and characterize advanced materials for biomedical and other applications. The research is a multi-displinary program including materials science, polymer chemistry, surface and interface science, biotechnology and nanotechnology.

Specifically, the current research focuses on 1) creating programmable matrix with multifarious properties in order to recapitulate the dynamic nature of native tissue for regenerative medicine and disease modeling; 2) developing stimuli-responsive theranostics with the ability of detecting, diagnosis and treatment of diseases for personalized medicine; and 3) developing point-of-care devices for medical diagnosis, environmental monitoring, and food safety.

PUBLICATIONS

17. C.-Y. Xue, D.Y. Wong, Andrea M. Kasko, Complex Dynamic Substrate Control: Dual-tone Hydrogel Photoresists Allow Double-dissociation of Topography and Modulus, Advanced Materials, 26(10), 1577-1583, 2014.[Link]

16. S. Choi, B-C Choi, C.-Y. Xue, Deborah E. Leckband, Protein Adsorption Mechanisms Determine the Efficiency of Thermally Controlled Cell Adhesion on Poly(N-isopropyl acrylamide) Brushes, Biomacromolecules, 14(1), 92-100, 2013.[Link]

15. C.-Y. Xue, C. Choi, S. Choi, Paul V. Braun and Deborah E. Leckband, Protein Adsorption Modes Determine Reversible Cell Attachment on Poly(N-isopropylacrylamide) Brushes, Advanced Functional Materials, 22(11), 2394-2401, 2012.[Link]

14. Nicolas Brouette, C.-Y. Xue, Michael Haertlein, Martine Moulin, Giovanna Fragneto, Deborah E. Leckband, Avraham Halperin, and Michele Sferrazza, Protein Adsorption Properties of OEG Monolayers and Dense PNIPAM Brushes Probed by Neutron Reflectivity, The European Physical Journal Special Topics, 213, 343-353, 2012.[Link]

13. C.-Y. Xue, N. Yonet-Tanyeri, Nicolas Brouette, Michele Sferrazza, Paul V. Braun, and Deborah E. Leckband, Protein Adsorption on Poly(N-isopropylacrylamide) Brushes: Dependence on Grafting Density and Chain Collapse, Langmuir, 27(14), 8810-8818, 2011.[Link] 12. C.-Y. Xue, W. Zhang, Wan Hui Stella Choo, and K.-L Yang, Simplest Method for Creating Micropatterned Nanostructures on PDMS with UV Light, Langmuir, 27(22), 13410-13414, 2011.[Link]

11. W. Zhang, W.T. Ang, C.-Y. Xue, and K.-L Yang, Minimizing Nonspecific Protein Adsorption in Liquid Crystal Immunoassays by Using Surfactants, ACS Applied Materials & Interfaces, 3(9), 3496-3500, 2011.[Link]

10. C.-Y. Xue, S.Y. Chin, Saif A. Khan, K.-L Yang, UV-Defined Flat PDMS Stamps Suitable for Microcontact Printing, Langmuir, 26 (5), 3739-3743, 2010.[Link]

9. W. Zhang, C.-Y. Xue, K.-L Yang, A Method of Printing Uniform Protein Lines by Using Flat PDMS Stamps, Journal of Colloid and Interface Science, 353 (1), 143-148, 2011.[Link]

8. C.-Y. Xue, Saif A. Khan, K.-L Yang, One-step UV Lithography for Activation of Inert Hydrocarbon Monolayers and Preparation of Protein Micropatterns, Journal of Colloid and Interface Science, 344 (1), 48-53, 2010.[Link]

7. C.-Y. Xue, Saif A. Khan, K.-L Yang, Exploring Optical Properties of Liquid Crystals for Developing Label-Free and High Throughput Microfluidic Immunoassays, Advanced Materials, 21 (2), 198-202, 2009.[Link] Highlighted by NPG Asia Materials, doi:10.1038/asiamat.2009.122, (2009).[Link]

6. Deny Hartono, C.-Y. Xue, Lin-Yue Lanry Yung, K.-L Yang, Decorating Liquid Crystal Surfaces with Proteins for Real-Time Detection of Specific Protein–Protein Binding, Advanced Functional materials, 19 (22), 3574-3579, 2009.[Link]

5. C.-Y. Xue, Deny Hartono, K.-L Yang, Controlling and Manipulating Supported Phospholipid Monolayers as Soft Resist Layers for Fabricating Chemically Micropatterned Surfaces, Langmuir, 24 (19), 11282-11286, 2008.[Link]

4. C.-Y. Xue, K.-L Yang, Dark-to-Bright Optical Responses of Liquid Crystals Triggered by Proteins Absorbed on Solid Surfaces, Langmuir, 24 (2), 563-567, 2008.[Link]

3. C.-Y. Xue, K.-L Yang, Chemical Modifications of Inert Organic Monolayers with Oxygen Plasma for Biosensor Applications, Langmuir, 23 (10), 5831-5835, 2007.[Link]

2. Y.T. Chen, T.Q. Liu, C.-Y. Xue, Y. Liu, Effects of Nanotopography of Bioactive Surface on Pseudomonas Fluorescence Cell Adhesion, Journal of Biomedical Engineering, 22 (3), 443-447, 2005.

1. C.-Y. Xue, T.Q. Liu, D. Ge, X.Y. Sun, X.H. Ma, Optimal Protocols to Expand Neural Stem Cells in Rotating Wall Vessel Bioreactor, Journal of Biomedical Engineering, 22 (3 Suppl.), 85-86, 2005.

PATENTS

2. K.-Y. Yang, C. -Y. Xue and Saif. A. Khan, Bioassay using Liquid Crystals, US 61/103,020, World Intellectual property Publication (WO 2010/042070), 2010.

1. K.-Y. Yang, C. -Y. Xue, UV Lithography on Polymer Surfaces for Fabricationg Microstructures and Microfluidic Channels, US 61/321,556, 2010.

AWARDS

Shen Postdoctoral Fellowship, University of Illinois at Urbana-Champaign, 2010

Chemical Engineering Graduate Student Fellowship, National University of Singapore, 2005-2009

Outstanding Graduate Student, Dalian University of Technology, 2003/2004/2005

INDEPENDENT REVIEWER

Chemical Society Reviews

Chemical Communications

ACS Applied Materials & Interfaces

Applied Surface Science ChemPhysChem  

Journal of Colloid and Interface Science

Journal of Materials Chemistry A

Journal of Materials Chemistry B

Journal of Materials Chemistry C

International Journal of Nanomedicine

Journal of Nanomaterials

Microscopy Research and Technique

RSC Advances