薛长颖

基本信息Personal Information

教授 硕士生导师

性别 : 女

毕业院校 : 新加坡国立大学

学位 : 博士

在职信息 : 在职

所在单位 : 生命科学与技术学院

学科 : 生物化工 生物医学工程

办公地点 : 辽宁省大连市高新园区凌工路2号(116024)

Email :

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个人简介Personal Profile

薛长颖,教授,大连理工大学"星海青年千人"入选者。2002、2005年于大连理工大学获得学士和硕士学位;2010年于新加坡国立大学获得博士学位;2009-2012年在美国伊利诺伊州立大学香槟分校从事博士后研究;2012-2015年在美国加州大学洛杉矶分校从事助理研究员工作。致力于先进生物功能材料、材料表界面、组织再生、生物传感器等研究。

实验室长期招收博士后,请发简历至changyingxue@dlut.edu.cn

研究领域
主要研究目标:设计、合成和表征用于生物医学领域的新材料;集中在先进智能材料和仿生材料研究开发、表面/界面分子工程、化学/生物分子传感器研究、体外仿生细胞微环境构建等;研究项目涉及材料科学、高分子化学、纳米科学、生物科学与技术、及胶体表面化学等多学科交叉领域。

研究内容
现阶段,我们的研究方向主要集中在以下三方面:
1.设计合成智能响应(如温度响应、光响应)材料,体外构建仿生细胞生长微环境,用于组织再生、药物筛选及疾病模型构建;
2.材料表面修饰及功能化,特别是设计修饰纳米材料,使其集诊断-治疗-追踪监测多功能于一体,用于智能化、个体化医药;
3.开发便携式分子检测与诊断装置,特别是研究开发免标记液晶检测技术。


发表论文
1.    C.-Y. Xue, D.Y. Wong, Andrea M. Kasko, Complex Dynamic Substrate Control: Dual-tone Hydrogel Photoresists Allow Double-dissociation of Topography and Modulus, Advanced Materials, 26(10), 1577-1583, 2014.                              
2.    S. Choi, B-C Choi, C.-Y. Xue, Deborah E. Leckband, Protein Adsorption Mechanisms Determine the Efficiency of Thermally Controlled Cell Adhesion on Poly(N-isopropyl acrylamide) Brushes, Biomacromolecules, 14(1), 92-100, 2013.        
3.    C.-Y. Xue, C. Choi, S. Choi, Paul V. Braun and Deborah E. Leckband, Protein Adsorption Modes Determine Reversible Cell Attachment on Poly(N-isopropylacrylamide) Brushes, Advanced Functional Materials,  22(11), 2394-2401, 2012.      
4.    Nicolas Brouette, C.-Y. Xue, Michael Haertlein, Martine Moulin, Giovanna Fragneto, Deborah E. Leckband, Avraham Halperin, and Michele Sferrazza, Protein Adsorption Properties of OEG Monolayers and Dense PNIPAM Brushes Probed by Neutron Reflectivity, The European Physical Journal Special Topics, 213, 343-353, 2012.                
5.    C.-Y. Xue, N. Yonet-Tanyeri, Nicolas Brouette, Michele Sferrazza, Paul V. Braun, and Deborah E. Leckband, Protein Adsorption on Poly(N-isopropylacrylamide) Brushes: Dependence on Grafting Density and Chain Collapse, Langmuir, 27(14), 8810-8818, 2011.      
6.    C.-Y. Xue, W. Zhang, Wan Hui Stella Choo, and K.-L Yang, Simplest Method for Creating Micropatterned Nanostructures on PDMS with UV Light, Langmuir, 27(22), 13410-13414, 2011.        
7.    W. Zhang, W.T. Ang, C.-Y. Xue, and K.-L Yang, Minimizing Nonspecific Protein Adsorption in Liquid Crystal Immunoassays by Using Surfactants, ACS Applied Materials & Interfaces, 3(9), 3496-3500, 2011.
8.    C.-Y. Xue, S.Y. Chin, Saif A. Khan, K.-L Yang, UV-Defined Flat PDMS Stamps Suitable for Microcontact Printing, Langmuir, 26 (5), 3739-3743, 2010.      
9.    W. Zhang, C.-Y. Xue, K.-L Yang, A Method of Printing Uniform Protein Lines by Using Flat PDMS Stamps, Journal of Colloid and Interface Science, 353 (1), 143-148, 2011.      
10.    C.-Y. Xue, Saif A. Khan, K.-L Yang, One-step UV Lithography for Activation of Inert Hydrocarbon Monolayers and Preparation of Protein Micropatterns, Journal of Colloid and Interface Science, 344 (1), 48-53, 2010.      
11.    C.-Y. Xue, Saif A. Khan, K.-L Yang, Exploring Optical Properties of Liquid Crystals for Developing Label-Free and High Throughput Microfluidic Immunoassays, Advanced Materials, 21 (2), 198-202, 2009. Highlighted by NPG Asia Materials, doi:10.1038/asiamat.2009.122, (2009).      
12.    Deny Hartono, C.-Y. Xue, Lin-Yue Lanry Yung, K.-L Yang, Decorating Liquid Crystal Surfaces with Proteins for Real-Time Detection of Specific Protein–Protein Binding, Advanced Functional Materials, 19 (22), 3574-3579, 2009.                    
13.    C.-Y. Xue, Deny Hartono, K.-L Yang, Controlling and Manipulating Supported Phospholipid Monolayers as Soft Resist Layers for Fabricating Chemically Micropatterned Surfaces, Langmuir, 24 (19), 11282-11286, 2008.                        
14.    C.-Y. Xue, K.-L Yang, Dark-to-Bright Optical Responses of Liquid Crystals Triggered by Proteins  Absorbed on Solid Surfaces, Langmuir, 24 (2), 563-567, 2008.          
15.    C.-Y. Xue, K.-L Yang, Chemical Modifications of Inert Organic Monolayers with Oxygen Plasma for Biosensor Applications, Langmuir, 23 (10), 5831-5835, 2007.              
16.    Y.T. Chen, T.Q. Liu, C.-Y. Xue, Y. Liu, Effects of Nanotopography of Bioactive Surface on Pseudomonas Fluorescence Cell Adhesion, Journal of Biomedical Engineering, 22 (3), 443-447, 2005.
17.    C.-Y. Xue, T.Q. Liu, D. Ge, X.Y. Sun, X.H. Ma, Optimal Protocols to Expand Neural Stem Cells in Rotating Wall Vessel Bioreactor, Journal of Biomedical Engineering, 22 (3 Suppl.), 85-86, 2005.


专利
1.  K.-Y. Yang, C. -Y. Xue and Saif. A. Khan, Bioassay using Liquid Crystals, US 61/103,020, World Intellectual Property Publication (WO 2010/042070), 2010.    
2.  K.-Y. Yang, C. -Y. Xue, UV Lithography on Polymer Surfaces for Fabricationg Microstructures and Microfluidic Channels, US 61/321,556, 2010.

  • 教育经历Education Background
  • 工作经历Work Experience
  • 研究方向Research Focus
  • 社会兼职Social Affiliations
  • 先进生物功能材料
    表界面科学与工程
    生物传感器
    组织再生