教授 博士生导师 硕士生导师
主要任职: 医学部党委书记兼常务副部长
性别: 男
毕业院校: 复旦大学
学位: 博士
所在单位: 生物医学工程学院
学科: 生物医学工程
电子邮箱: krqin@dlut.edu.cn
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论文类型: 期刊论文
发表时间: 2018-08-01
发表刊物: MICROFLUIDICS AND NANOFLUIDICS
收录刊物: SCIE
卷号: 22
期号: 8
ISSN号: 1613-4982
关键字: Dynamic biochemical signals; Microfluidics; Transmission characteristics; Nonlinear modulation; Low-pass filtering
摘要: A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the transmission characteristics of dynamic biochemical signals in pulsatile flows by analytically solving the convection-diffusion equation for the time-dependent Taylor-Aris dispersion with perturbation method. We prove that the transmission of dynamic biochemical signals in pulsatile flows is subject to the two correlate effects: low-pass filtering and nonlinear amplitude-frequency modulation. These two effects are systematically characterized and the influence factors are studied, including the biochemical signal frequency, the pulsatile flow frequency, the transmission distance and the average pulsatile flow rate. We concluded that the balance of multiple factors should be taken into account for better loading biochemical signals on cells cultured in the microfluidic channel.