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栾雨时
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教授   博士生导师   硕士生导师

主要任职: 无

性别: 男

毕业院校: 东北师范大学

学位: 博士

在职信息:在职

所在单位: 生物工程学院

学科: 生物化学与分子生物学 生物化工 生物工程与技术

办公地点: 生物工程学院401室

联系方式: 13624087256

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个人简介

长期从事植物分子生物学、基因工程领域的研究工作,在植物非编码RNA、转录因子的发现及功能鉴定方面独树一帜,尤其是以番茄与致病疫霉为材料进行的植物与微生物分子互作研究,结合大量的生物信息学预测、分析以及先进的分子生物学实验技术,取得了众多突破性的成果,论文发表在植物科学领域的TOP (11/234) 期刊-“Plant Cell and Environment”、植物科学领域的TOP (13/234) 期刊-“Plant Journal” (3)、食品科学领域的TOP (6/139) 期刊-“Food Chemistry”、园艺学领域的TOP (1/36) 期刊-“Horticulture Research” (2)、农艺学领域的TOP (5/91) 及园艺学领域的TOP (2/36) 期刊-“Theoretical and Applied Genetics”等上。多年来,陆续得到 5 项国家自然科学基金项目的支持;共发表论文 148 篇,其中SCI收录 81 篇,目前仅存 2 ESI高被引论文。

指导的博士、硕士研究生有 5 人、次获得国家奖学金(2018年姜宁、2017年崔军、2015年刘震、2014年李景滨、2014年王炜晨、2012年李景滨),有 2 人获得学业奖学金,有 8 人被评为优秀研究生,有 4 人获得大连理工大学优秀硕士学位论文;指导的本科生在进行大学生创新项目期间,多数人有论文发表,先后有 2 人被保送到清华大学继续深造。

目前正在指导 7 名博士生、 5 名硕士生。

欢迎志于从事相关研究的人员加盟

近年来发表的主要文章有:

1.       Jiang Ning#, Cui Jun#, Hou Xinxin, Yang Guanglei, Xiao Yu, Han Lu, Meng Jun*, Luan Yushi*. Sl-lncRNA15492 interacts with Sl-miR482a and affects Solanum lycopersicum immunity against Phytophthora infestans. Plant Journal, 2020. May 20. https://onlinelibrary.wiley.com/doi/10.1111/tpj.14847 (SCI IF6.141, JCR Q1, TOP期刊)

2.       Wekesa Jael Sanyanda, Meng Jun*, Luan Yushi. A deep learning model for plant lncRNA-protein interaction prediction with graph attention. Molecular Genetics and Genomics, 2020 May 15. doi: 10.1007/s00438-020-01682-w. https://link.springer.com/article/10.1007/s00438-020-01682-w (SCI入藏号: WOS:000532870000001, IF2. 797, JCR Q3).

3.       Hou Xinxin, Cui Jun, Liu Weiwei, Jiang Ning, Zhou Xiaoxu, Qi Hongyan, Meng Jun*, Luan Yushi*. LncRNA39026 enhances tomato resistance to Phytophthora infestans by decoying miR168a and inducing PR genes expression. Phytopathology, 2020, 110(4): 873-880. (SCI IF3.234, JCR Q1, TOP期刊).

4.       Kang Qiang, Meng Jun*, Cui Jun, Luan Yushi*, Chen Ming. PmliPred: a method based on hybrid model and fuzzy decision for plant miRNA-lncRNA interaction prediction. Bioinformatics, 2020, 36(10), 2020, 2986-2992. (SCI入藏号: WOS:000537447900003, IF5.61, JCR Q1).

5.       Wekesa Jael Sanyanda, Meng Jun*, Luan Yushi. Multi-feature fusion for deep learning to predict plant lncRNA-protein interaction. Genomics, 2020, 112(5): 2028-2036. (SCI IF6.205, JCR Q1)

6.       Hong Yuhui, Meng Jun, Zhang Min, Luan Yushi*. Identification of tomato circular RNAs responsive to Phytophthora infestans. Gene, 2020, 746:144652. (SCI入藏号: WOS:000530711400006, IF2.984, JCR Q2).

7.       Wekesa Jael Sanyanda*, Luan Yushi, Meng Jun. Predicting Protein Functions Based on Differential Co-expression and Neighborhood Analysis. Journal of Computational Biology. 2020, 27(4): 1-18. (SCI入藏号: WOS: 000526704400001, IF1.054, JCR Q4).

8.       Liu Yarong, Cui Jun, Zhou Xiaoxu, Luan Yushi*, Luan Feishi*. Genome-wide identification, characterization and expression analysis of the TLP gene family in melon (Cucumis melo L.). Genomics, 2020, 112(3): 2499-2509 (SCI入藏号: WOS:000519997800043, IF6.205, JCR Q1).

9.       Zhou Xiaoxu, Cui Jun, Cui Haonan, Jiang Ning, Hou Xinxin, Liu Shi, Gao Peng, Luan Yushi*, Meng Jun*, Luan Feishi*. Identification of lncRNAs and their regulatory relationships with target genes and corresponding miRNAs in melon response to powdery mildew fungi. Gene, 2020, 735:144403. (SCI入藏号: WOS:000518870500011, IF2.984, JCR Q2).

10.   Zhang Peng, Meng Jun*, Luan Yushi, Liu Chanjuan. Plant miRNA-lncRNA Interaction Prediction Prediction with the Ensemble of CNN and IndRNN. Interdisciplinary Sciences: Computational Life Sciences. 2020, 12: 82-89. (SCI入藏号: WOS: 000511625600009, IF1.512, JCR Q3).

11.   Cui Jun, Jiang Ning, Hou Xinxin, Wu Sihan, Zhang Qiang, Meng Jun*, Luan Yushi*. Genome-wide Identification of LncRNAs and Analysis of CeRNA Networks during Tomato Resistance to Phytophthora infestans. Phytopathology, 2020, 110(2): 456-464. (SCI入藏号: WOS:000510421600022, IF3.234, JCR Q1, TOP期刊).

12.   Sun Xiaodong, Lyu Guozhong*, Luan Yushi*, Yang Hong, Zhao Zhihui. Metabolomic study of the soybean pastes fermented by the single species Penicillium glabrum GQ1-3 and Aspergillus oryzae HGPA20. Food Chemistry. 2019. 295: 622-629. (SCI入藏号: WOS:000470098000073, IF6.306, JCR Q1, TOP期刊).

13.   Hong Yuhui, Meng Jun, He Xiaoli, Zhang Yuanyuan, Luan Yushi*. Overexpression of MiR482c in Tomato Induces Enhanced Susceptibility to Late Blight. Cells. 2019, 8(8): 822. (SCI入藏号: WOS:000484537500055, IF 4.366, JCR Q2).

14.   Meng Jun, Chang Zheng, Zhang Peng, Shi Wenhao, Luan Yushi*. lncRNA-LSTM: Prediction of Plant Long Non-coding RNAs Using Long Short-Term Memory Based on p-nts Encoding. International Conference on Intelligent Computing, 2019, 11645: 347-357. ( EI收录号: 20193407326655).

15.   Zhou Haoran, Luan Yushi, WekesaJael Jael, Meng Jun*. Prediction of Plant lncRNA-Protein Interactions Using Sequence Information Based on Deep Learning. International Conference on Intelligent Computing, 2019, 11645: 358-368. ( EI收录号: 20193407326656).

16.   Wekesa Jael Sanyanda, Luan Yushi, Chen Ming, Meng Jun*. A Hybrid Prediction Method for Plant lncRNA-Protein Interaction. Cells. 2019, 8(6): 521. (SCI入藏号: WOS: 000475309200009, IF4.366, JCR Q2).

17.   Ismalia Bouba, Kang Qiang, Luan Yushi, Meng Jun*. Predicting miRNA-lncRNA interactions and recognizing their regulatory roles in stress response of plants. Mathematical Biosciences. 2019, 312(6): 67-76. (SCI入藏号: WOS: 000469895200007, IF1.649, JCR Q3).

18.   Chen Lei, Meng Jun, He Xiaoli, Zhang Ming, Luan Yushi*. Solanum lycopersicum microRNA1916 targets multiple target genes and negatively regulates the immune response in tomato. Plant Cell and Environment. 2019, 42(4): 1393-1407. (SCI入藏号: WOS:000462360300024, IF6.362, JCR Q1, TOP期刊)

19.   Cui Jun, Jiang Ning, Meng Jun*, Yang Guanglei, Liu Weiwei, Zhou Xiaoxu, Ma Ning, Hou Xinxin, Luan Yushi*. LncRNA33732-RESPIRATORY BURST OXIDASE module associated with WRKY1 in tomato- Phytophthora infestans interactions. Plant Journal, 2019, 97(5): 933-946. (SCI入藏号: WOS:000462684900010, IF6.141, JCR Q1, TOP期刊)

20.   Jiang Ning, Cui Jun, Shi Yunsheng, Yang Guanglei, Zhou Xiaoxu, Hou Xinxin, Meng Jun*, Luan Yushi*, Tomato lncRNA23468 functions as a competing endogenous RNA to modulate NBS-LRR genes by decoying miR482b in the tomato-Phytophthora infestans interaction. Horticulture Research. 2019, 6 :28. (SCI入藏号: WOS:000457953200014, IF5.404, JCR Q1, TOP期刊).

21.   Chen Lei, Meng Jun, Luan Yushi*. miR1916 plays a role as a negative regulator in drought stress resistance in tomato and tobacco. Biochemical and Biophysical Research Communications. 2019, 508(2): 597-602. (SCI入藏号: WOS:000456635900040, IF 2.985, JCR Q3)

22.   Jiang Ning, Cui Jun, Yang Guanglei, He Xiaoli, Meng Jun, Luan Yushi*, Comparative transcriptome analysis shows the defense response networks regulated by miR482b. Plant Cell Reports. 2019, 38(1):1-13. (SCI入藏号: WOS:000454913700001, IF3.825, JCR Q1)

23.   Hong Yuhui, Cui Jun, Liu Zhen, Luan Yushi*. SpWRKY6 Acts as a Positive Regulator during Tomato Resistance to Phytophthora infestans Infection. Biochemical and Biophysical Research Communications. 2018, 506(4): 787-792. (SCI入藏号: WOS:000452249100003, IF 2.985, JCR Q3)

24.   Cui Jun, Jiang Ning, Zhou Xiaoxu, Hou Xinxin, Yang Guanglei, Meng Jun*, Luan Yushi*. Tomato MYB49 enhances resistance to Phytophthora infestans and tolerance to water deficit and salt stress. Planta, 2018. 248(6): 1487-1503. (SCI入藏号: WOS:000450563300012, IF3.06, JCR Q1).

25.   Sun Xiaodong, Lyu Guozhong*, Luan Yushi*, Zhao Zhihui, Yang Hong, Su Dan. Analyses of microbial community of naturally homemade soybean pastes in Liaoning Province of China by Illumina Miseq Sequencing. Food Research International, 2018. 111: 50-57. (SCI入藏号: WOS:000441643400006, IF3.579, JCR Q1, TOP期刊).

26.   Jiang Ning, Cui Jun, Meng Jun, Luan Yushi*, A tomato NBS-LRR gene is positively involved in plant resistance to Phytophthora infestans. Phytopathology, 2018, 108(8): 980-987. (SCI入藏号: WOS:000439219600008, IF3.264, JCR Q1, TOP期刊).

27.   Cui Jun, Jiang Ning, Meng Jun, Hou Xinxin, Yang Guanglei, Luan Yushi*. Identification and characterization of defensin genes conferring Phytophthora infestans resistance in tomato. Physiological and Molecular Plant Pathology, 2018. 103: 28-35. (SCI入藏号: WOS: 000440563900005, IF1.678, JCR Q2).

28.   Cui Jun, Xu Pinsan, Meng Jun*, Li Jingbin, Jiang Ning, Luan Yushi*, Transcriptome signatures of tomato leaf induced by Phytophthora infestans and functional identification of transcription factor SpWRKY3. Theoretical and Applied Genetics. 2018, 131(4): 787-800 (SCI入藏号: WOS:000427584400003, IF3.926, JCR Q1, TOP期刊).

29.   Jiang Ning, Meng Jun*, Cui Jun, Sun Guangxin, Luan Yushi*, Function identification of miR482b, a negative regulator during tomato resistance to Phytophthora infestans. Horticulture Research. 2018, 5 :9. (SCI入藏号: WOS:000427835600001, IF3.64, JCR Q1, TOP期刊; 高被引论文).

30.   Meng Jun, Jiang Dingling, Chang Zheng, Luan Yushi*, Information Fusion and Feature Selection Technique. INTELLIGENT COMPUTING THEORIES AND APPLICATION, PT II, Lecture Notes in Computer Science, 2018, 10955: 318-329. (SCI入藏号: WOS: 000484469700039, IF0.402, JCR Q4).

31.   Meng Jun, Jiang Dingling, Zhang Jing, Luan Yushi*, Ensemble classification for gene expression data based on parallel clustering. International Journal of Data Mining and Bioinformatics, 2018, 20(3): 213-229. (SCI入藏号: WOS: 000444598700002, IF0.789, JCR Q4).

32.   Luan Yushi, Cui Jun, Li Jie, Jiang Ning, Liu Ping, Meng Jun*, Effective enhancement of resistance to Phytophthora infestans by overexpression of miR172a and b in Solanum lycopersicum. Planta. 2018, 247:127-138. (SCI入藏号: WOS:000419584800008, IF3.06, JCR Q1).

33.   Liu Weiwei, Meng Jun*, Cui Jun, Luan Yushi*, Characterization and Function of MicroRNA*s in Plants. Frontiers in Plant Science. 2017, 8: 2200 (SCI入藏号: WOS:000418586100001, IF3.678, JCR Q1)

34.   Chen Lei, Meng Jun*, Zhai Junmiao, Xu Pinsan, Luan Yushi*. MicroRNA396a-5p and -3p induce tomato disease susceptibility by suppressing target genes and upregulating salicylic acid. Plant Science. 2017, 265 (12): 177-187 (SCI入藏号: WOS:000419416000016, IF3.712, JCR Q1)

35.   Cui Jun, Jiang Ning, Meng Jun*, Luan Yushi*, Genome-wide analysis of response regulator genes in Solanum lycopersicum. Bioinformatics Research and Applications. 2017, 379-384. (SCI入藏号: WOS:000434328000038, EI收录号: 20172503793523).

36.   Meng Jun, Zhang Jing, Luan Yushi*, He Xinyu, Li Lishuang, Zhu Yuanfeng, Parallel gene selection and dynamic ensemble pruning based on Affinity Propagation. Computers in Biology and Medicine. 2017, 87: 8-21 (SCI入藏号: WOS:000409151600002, IF2.115, JCR Q2)

37.   Cui Jun, Luan Yushi*, Jiang Ning, Bao Hang, Meng Jun*, Comparative transcriptome analysis between resistant and susceptible tomato allows the identification of lncRNA16397 conferring resistance to Phytophthora infestans by co-expressing glutaredoxin. Plant Journal, 2017, 89(3): 577-589. (SCI入藏号: WOS:000395802900012, IF5.775, JCR Q1, TOP期刊; 高被引论文)

38.   Luan Yushi, Cui Jun, Wang Weichen, Meng Jun*, MiR1918 enhances tomato sensitivity to Phytophthora infestans infection. Scientific Reports. 2016, 6:35858. (SCI入藏号: WOS:000386006100001, IF4.259, JCR Q1)

39.   Liu Zhen, Luan Yushi*, Li Jingbin. Molecular cloning and expression analysis of SpWRKY6 from Solanum pimpinellifolium L3708. Biologia Plantarum. 2016, 60(2):226-234. (SCI入藏号: WOS:000375059800003, IF1.551, JCR Q2)

40.   Meng Jun, Hao Han, Luan Yushi*, Classifier Ensemble Selection based on Affinity Propagation Clustering. Journal of Biomedical Informatics. 2016, 60:234-242. (SCI入藏号: WOS:000384704100024, IF2.753, JCR Q1, EI)

41.   Meng Jun, Wekesa Jael-Sanyanda, Shi Guanli, Luan Yushi*, Protein function prediction based on data fusion and functional interrelationship. Mathematical Biosciences. 2016, 274:25-32. (SCI入藏号: WOS:000373545200004, IF1.246, JCR Q3, EI)

42.   Liu Zhen, Luan Yushi*, Li Jingbin, Yin Yali. Expression of a tomato MYB gene in transgenic tobacco increases resistance to Fusarium oxysporum and Botrytis cinerea. European Journal of Plant Pathology. 2016, 144(3): 607-617. (SCI入藏号: WOS:000368998100012, IF1.478, JCR Q2)

43.   Meng Jun, Shi Guanli, Luan Yushi*, Plant miRNA function prediction based on functional similarity network and transductive multi-label classification algorithm. Neurocomputing. 2016, 179: 283-289. (SCI入藏号: WOS:000370090300026, IF3.317, JCR Q1, EI)

44.   Meng Jun, Zhang Xin, Luan Yushi*, Global Propagation Method for Predicting Protein Function by Integrating Multiple Data Sources. Current Bioinformatics. 2016, 11(2):186-194.(SCI入藏号: WOS:000373457500006, IF0.60, JCR Q4)

45.   Han Lu (本科生), Luan Yushi*. Horizontal Transfer of Small RNAs to and from Plants. Frontiers in Plant Science. 2015, 6:1113. (SCI入藏号: WOS:000366860600001, IF4.495, JCR Q1).

46.   Chen Lei, Luan Yushi*, Zhai Junmiao. Sp-miR396a-5p acts as a stress-responsive genes regulator by conferring tolerance to abiotic stresses and susceptibility to Phytophthora nicotianae infection in transgenic tobacco. Plant Cell Reports. 2015, 34(12): 2013-2025. (SCI入藏号: WOS:000364530300001, IF3.088, JCR Q1)

47.   Meng Jun, Liu Dong, Luan Yushi*, Inferring plant microRNA functional similarity using a weighted protein-protein interaction network. BMC Bioinformatics. 2015, 16: 360. (SCI入藏号: WOS: 000364115400001, IF2.435, JCR Q1, EI)

48.   Li Jingbin, Luan Yushi*, Liu Zhen. Overexpression of SpWRKY1 promotes resistance to Phytophthora nicotianae and tolerance to salt and drought stress in transgenic tobacco. Physiologia Plantarum, 2015, 155(3): 248-266. (SCI入藏号: WOS:000362888000003, IF3.52, JCR Q1)

49.   Li Jingbin, Luan Yushi*, Liu Zhen. SpWRKY1 mediates resistance to Phytophthora infestans and tolerance to salt and drought stress by modulating reactive oxygen species homeostasis and expression of defense-related genes in tomato. Plant Cell Tissue and Organ Culture. 2015, 123(1): 67-81. (SCI入藏号: WOS:000360945700007, IF2.39, JCR Q1, EI)

50.   Meng Jun, Li Rui, Luan Yushi*, Classification by integrating plant stress response gene expression data with biological knowledge. Mathematical Biosciences. 2015, 266(8): 65-72. (SCI入藏号: WOS:000358820100007, IF1.256, JCR Q3, EI)

51.   Wang Weichen, Luan Yushi*, The advance of tomato disease-related microRNAs. Plant Cell Reports. 2015, 34(7): 1089-1097 (SCI入藏号: WOS:000356051100001, IF3.088, JCR Q1)

52.   Luan Yushi, Cui Jun, Zhai Junmiao, Li Jie, Han Lu, Meng Jun*, High-throughput sequencing reveals differential expression of miRNAs in tomato inoculated with Phytophthora infestans. Planta. 2015, 241(6):1405-1416 (SCI入藏号: WOS:000354244700009, IF3.239, JCR Q1)

53.   Meng Jun, Zhang Jing, Luan Yushi*, Gene Selection Integrated with Biological Knowledge for Plant Stress Response Using Neighborhood System and Rough Set Theory. IEEE-Acm Transactions on Computational Biology and Bioinformatics, 2015, 12(2): 433-444 (SCI入藏号: WOS: 000352788300017, IF1.609, JCR Q2, EI)

54.   Meng Jun, Liu Dong, Sun Chao, Luan Yushi*, Prediction of plant pre-microRNAs and their microRNAs in genome-scale sequences using structure-sequence features and support vector machine. BMC Bioinformatics. 2014, 15:423. (SCI入藏号: WOS: 000348476000001, IF2.576, JCR Q1, EI)

55.   Meng Jun, Zhang Jing, Li Rui, Luan Yushi*, Gene selection using rough set based on neighborhood for the analysis of plant stress response. Applied Soft Computing, 2014, 25(12): 51-63 (SCI入藏号: WOS:000344460600005, IF2.81, JCR Q1, EI)

56.   Li Jingbin, Luan Yushi*, Yin Yali. SpMYB overexpression in tobacco plants leads to altered abiotic and biotic stress responses. Gene, 2014, 547(1): 145-151(SCI入藏号: WOS: 000339537600020, IF2.138, JCR Q3).

57.   Luan Yushi*, Wang Weichen, Liu Ping. Identification and functional analysis of novel and conserved microRNAs in tomato. Molecular Biology Reports, 2014, 41(8): 5385-5394(SCI入藏号: WOS: 000339910900054, IF2.024, JCR Q3).

58.   Meng Jun, Shi Lin, Luan Yushi*, Plant microRNA-Target Interaction Identification Model Based on the Integration of Prediction Tools and Support Vector Machine. PLoS ONE, 2014, 9(7): e103181 (SCI入藏号: WOS: 000339551100094, IF3.234, JCR Q1, EI).

59.   Li Jingbin, Luan Yushi*. Molecular cloning and characterization of a pathogen-induced WRKY transcription factor gene from late blight resistant tomato varieties Solanum pimpinellifolium L3708. Physiological and Molecular Plant Pathology, 2014, 87(7): 25-31(SCI入藏号: WOS: 000342077400005, IF1.407, JCR Q2).

60.   Cui Juanjuan, Luan Yushi*, Wang Weichen, Zhai Junmiao. Prediction and validation of potential pathogenic microRNAs involved in Phytophthora infestans infection. Molecular Biology Reports, 2014, 41(3):1879-1889(SCI入藏号: WOS: 000332000400075, IF2.024, JCR Q3).

61.   马宁, 刘亚荣, 崔军, 洪雨慧, 栾雨时*. 番茄蛋白酶抑制剂基因SLPI100的克隆、表达与生物信息学分析. 基因组学与应用生物学, 2019, 38(8): 1-11.

62.   贺晓丽, 刘萍, 栾雨时*. 番茄MIR398基因的克隆及其在烟草中的表达分析. 植物生理学报,2015, 51 (12): 2163-2168.

63.   崔娟娟,栾雨时*. 番茄生物胁迫相关miRNA的研究进展. 生命科学研究,2014186):533-538.

64.   肖裕 (本科生),栾雨时*. miR482介导的植物生物胁迫响应. 植物生理学报,2014506): 741-748.

65.   韩璐 (本科生),栾雨时*. miR168在植物中的研究进展. 基因组学与应用生物学,2014332):438-444.

66.   孙广鑫,栾雨时*,崔娟娟. 番茄中与致病密切相关miRNA的挖掘及特性分析. 遗传,2014361): 69-76.

教育经历

1977.9 - 1979.7 梅河口市第五高中  

1994.9 - 1997.7 东北师范大学   植物学   博士

1985.9 - 1988.7 吉林农业大学   植物学   硕士

1979.9 - 1983.7 吉林农业大学   植物学   学士

工作经历

1998.7 - 至今 大连理工大学   教师

1988.7 - 1998.6 吉林农业大学   教师

1983.7 - 1985.8 吉林省白山市蔬菜所   技术员

社会兼职
2014.1 - 至今  

《基因组学与应用生物学》期刊编委

2017.10 - 至今  

中国园艺学会分子育种分会理事

2014.11 - 2022.8  

中国生物化学与分子生物学会农业分会理事

研究方向

植物基因工程: 探寻、发现并克隆重要的基因;借助过表达、沉默等技术掌握基因的特性及功能;合理、有效地利用功能基因服务于农业生产和人民生活。


植物与微生物互作: 查明有害(有益)细菌、真菌、病毒等在侵染植物过程中的作用机制,为确保植物健康、快速生长奠定基础。


非编码RNA调控与功能: 鉴定植物非编码RNA,阐明其功能及作用机制;通过非编码RNA组学的研究,构建并完善相关调控网络;为揭示生命的奥秘添砖加瓦。

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