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论文类型：期刊论文

发表时间：2017-07-05

发表刊物：20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT)

收录刊物：SCIE、CPCI-S、PubMed、Scopus

卷号：25

期号：7

页面范围：1522-1530

ISSN号：1525-0016

关键字：adverse outcome pathway (AOP),engineered nanomaterial (ENM),nanomedicine,nanosafety,predictive toxicology,safer design,structure-activity relationship (SAR)

摘要：Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.