张志超

个人信息Personal Information

教授

博士生导师

硕士生导师

性别:女

毕业院校:大连理工大学

学位:博士

所在单位:化学学院

学科:化学生物学. 药理学. 细胞生物学

办公地点:Chemical complex building,D513

联系方式:zczhang@dlut.edu.cn 13942696903

电子邮箱:zczhang@dlut.edu.cn

扫描关注

论文成果

当前位置: 中文主页 >> 科学研究 >> 论文成果

The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells

点击次数:

论文类型:期刊论文

发表时间:2012-10-28

发表刊物:CANCER LETTERS

收录刊物:SCIE、Scopus

卷号:323

期号:2

页面范围:180-187

ISSN号:0304-3835

关键字:Autophagy; ER stress; BH3 mimetic; Bcl-2

摘要:Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by Si. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3-methyladenine (3-MA) or chloroquine (CQ) increased S1-induced apoptosis. In conclusion, autophagy plays an important role in S1-induced U251 cell death. (c) 2012 Elsevier Ireland Ltd. All rights reserved.