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论文类型：期刊论文
发表时间：2011-01-01
发表刊物：MATHEMATICAL AND COMPUTER MODELLING
收录刊物：SCIE、EI、Scopus
卷号：53
期号：1-2
页面范围：168-178
ISSN号：0895-7177
关键字：Nonlinear dynamical system; Optimal control; Switching instant; Constraint transcription; Fed-batch fermentation
摘要：The mathematical model and optimal control of microbial fed-batch fermentation is considered in this paper. Since it is decisive for increasing the productivity of 1,3-propanediol (1,3-PD) to optimize the feeding rate of glycerol and the switching instants between the batch and feeding processes in the fermentation process, we propose a new nonlinear dynamical system to formulate the process. In the system, the switching instants are variable and the feed rate of glycerol is regarded as the control function. Some important properties of the proposed system and its solution are then discussed. To maximize the concentration of 1,3-PD at the terminal time, an optimal control model involving the proposed system and subject to continuous state inequality constraints is established. The existence of the optimal control of the model is also proved. Finally, a computational approach is constructed on the basis of constraint transcription and smoothing approximation techniques. Numerical results show that the concentration of 1,3-PD at the terminal time can be increased considerably. (C) 2010 Elsevier Ltd. All rights reserved.