Apatite Formation on Poly(aryl ether sulfone ketone) Surfaces by Means of Polydopamine Layers Functionalized with Phosphonate Groups
- 论文类型：期刊论文
- 发表时间：2018-07-09
- 发表刊物：ADVANCED MATERIALS INTERFACES
- 收录刊物：SCIE
- 文献类型：J
- 卷号：5
- 期号：13
- ISSN号：2196-7350
- 关键字：apatite coatings; phosphonate groups; poly(aryl ether sulfone ketone);
polydopamine
- 摘要：Poly(aryl ether sulfone ketone) containing phthalazinone and biphenyl moieties (PPBESK) is a promising candidate for replacing metal bone implants. Apatite synthesized by polydopamine-assisted hydroxyapatite formation (pHAF) is a promising coating for bone-implant application. In this study, a modified pHAF technique is employed to induce the formation of apatite onto PPBESK while phosphonate groups, as potent inducers of apatite formation, are introduced through modification of a polydopamine (PDA) layer. The PPBESK layer and surface-modified samples are evaluated by Raman spectroscopy, contact angle measurement, scanning electron microscope (SEM), and X-ray photoelectron spectroscopy, respectively. The surface roughness of the samples increases following self-polymerization of dopamine and decreases after reacting with POCl3. PPBESK water contact angle reduces significantly after coating with PDA. Microstructural and compositional analyses by SEM and X-ray diffraction reveal that apatite coating induced by phosphonate groups exhibits a greater quantity of apatite formation, a higher ratio of Ca/P than that induced by a pristine PDA layer. The surfaces are characterized by culturing with MC3T3-E1 preosteoblasts. Apatite induced by phosphonate group conjugated to PDA layer on PPBESK surface promotes cytocompatibility and osteogenesis of MC3T3-E1 preosteoblasts in vitro.
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