更多
论文成果
Apatite Formation on Poly(aryl ether sulfone ketone) Surfaces by Means of Polydopamine Layers Functionalized with Phosphonate Groups
点击次数:
论文类型: 期刊论文
发表时间: 2018-07-09
发表刊物: ADVANCED MATERIALS INTERFACES
收录刊物: SCIE
卷号: 5
期号: 13
ISSN号: 2196-7350
关键字: apatite coatings; phosphonate groups; poly(aryl ether sulfone ketone); polydopamine
摘要: Poly(aryl ether sulfone ketone) containing phthalazinone and biphenyl moieties (PPBESK) is a promising candidate for replacing metal bone implants. Apatite synthesized by polydopamine-assisted hydroxyapatite formation (pHAF) is a promising coating for bone-implant application. In this study, a modified pHAF technique is employed to induce the formation of apatite onto PPBESK while phosphonate groups, as potent inducers of apatite formation, are introduced through modification of a polydopamine (PDA) layer. The PPBESK layer and surface-modified samples are evaluated by Raman spectroscopy, contact angle measurement, scanning electron microscope (SEM), and X-ray photoelectron spectroscopy, respectively. The surface roughness of the samples increases following self-polymerization of dopamine and decreases after reacting with POCl3. PPBESK water contact angle reduces significantly after coating with PDA. Microstructural and compositional analyses by SEM and X-ray diffraction reveal that apatite coating induced by phosphonate groups exhibits a greater quantity of apatite formation, a higher ratio of Ca/P than that induced by a pristine PDA layer. The surfaces are characterized by culturing with MC3T3-E1 preosteoblasts. Apatite induced by phosphonate group conjugated to PDA layer on PPBESK surface promotes cytocompatibility and osteogenesis of MC3T3-E1 preosteoblasts in vitro.

蹇锡高

教授   博士生导师   硕士生导师

性别: 男

毕业院校:大连工学院

学位: 硕士

所在单位:化工学院

学科:高分子材料. 高分子化学与物理. 膜科学与技术

联系方式:手机:13904286124

电子邮箱:jian4616@dlut.edu.cn

邮箱 : jian4616@dlut.edu.cn

辽ICP备05001357号 地址:中国·辽宁省大连市甘井子区凌工路2号 邮编:116024
版权所有:大连理工大学
访问量: 手机版 English 大连理工大学 登录

开通时间:..

最后更新时间:..