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论文类型：期刊论文

发表时间：2017-10-01

发表刊物：JOURNAL OF FUNCTIONAL FOODS

收录刊物：Scopus、SCIE

卷号：37

页面范围：339-353

ISSN号：1756-4646

关键字：Baicalein; Dietary supplement; Acarbose; SOCS3; Insulin sensitizer; Diabetes prevention

摘要：Baicalein, a major component in Scutellaria baicalensis and Oroxylum indicum, is used as dietary supplement in Asia. In this study, we characterized the insulin-sensitizing activity of baicalein and found that baicalein improved insulin resistance by reducing the expression of SOCS3, increasing the phosphorylation of IRS1 and Aktl, reducing the phosphorylation of GSK3 and increasing hepatic glycogen level. We further evaluated the preventive effect of baicalein combined with acarbose in mice, aiming to enhance the therapeutic effect and reduce the side-effects of acarbose. The combination reduced the relative risk of progression from prediabetes to diabetes by 83.3% and the dose of acarbose by 80%. The underlying mechanisms include reducing postprandial hyperglycemia, improving insulin resistance, improving lipid metabolism, and reducing oxidative stress. Our results suggest that the consumption of 195-780 mg/d baicalein might improve the efficacy of acarbose on diabetes prevention and reduce the side-effects of acarbose in long-term acarbose users. (C) 2017 Elsevier Ltd. All rights reserved.