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个人信息Personal Information
教授
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 有机化学
办公地点：化工实验楼E座514
联系方式：0411-84986324 13504280675
电子邮箱：xlianli@dlut.edu.cn
The novel anti-tumor agents of 4-triazol-1,8-naphthalimides: Synthesis, cytotoxicity, DNA intercalation and photocleavage
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论文类型：期刊论文
发表时间：2011-04-01
发表刊物：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
收录刊物：Scopus、SCIE、PubMed
卷号：46
期号：4
页面范围：1274-1279
ISSN号：0223-5234
关键字：Triazole; Intercalation; Anticancer; Naphthalimides
摘要：A novel series of 4-(4-phenyl-[1,2,3]-triazol-1-yl)-1,8-naphthalimide derivatives had been synthesized easily by employing "click reaction". For anti-tumor activity in vitro, all the compounds were found to be more toxic against MCF-7 than Hela and 7721 cells. 4a, 4b and 4e Showed improved cytotoxic activity against MCF-7 cells over Amonafide, in particular compound 4a, with an IC(50) could amount to 10(-7) M. The UV-vis spectra and Circular Dichroism titration indicated that the compounds behaved as effective DNA-intercalating agents. The investigation of their photo-damaging ability illuminated that these compounds could damage DNA effectively into form II and even form III. (c) 2011 Elsevier Masson SAS. All rights reserved.