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论文类型：期刊论文

发表时间：2011-03-25

发表刊物：TETRAHEDRON

收录刊物：Scopus、SCIE

卷号：67

期号：12

页面范围：2299-2304

ISSN号：0040-4020

关键字：Triazole; Intercalation; Anticancer; Naphthalimides

摘要：Two novel series of 3-1,2,3-triazol-1,8-naphthalimides 5a-e, 7a-e were synthesized easily by employing 'click reaction'. Their bioactivities were evaluated. Compounds 5a-e were found to be more toxic against MCF-7 cells while 7a-e were more potent against 7721 cells, in particular 7a, the IC50 value of which against cell lines of MCF-7 and 7721 was 0.348 mu M and 0.258 mu M, respectively. Due to the phenyl group linked to 1,2,3-triazole, compound 5a not only showed higher DNA affinity but also more efficient DNA damaging ability than compound 7a. (C) 2011 Elsevier Ltd. All rights reserved.