Copper-Catalyzed Direct Oxidative C-H Amination of Benzoxazoles with Formamides or Secondary Amines under Mild Conditions
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论文类型：期刊论文
发表时间：2011-07-01
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：PubMed、EI、SCIE
卷号：76
期号：13
页面范围：5444-5449
ISSN号：0022-3263
摘要：A facile, efficient, and practical method for copper-catalyzed direct C-H amination of benzoxazoles with formamides or secondary amines has been developed. The system can be performed in the absence of external base and only requires O(2) or even air as oxidant. A variety of substituted benzoxazol-2-amines were synthesized with moderate to excellent yield.