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A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy

Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-08-25

Journal: CHEMICAL COMMUNICATIONS

Included Journals: SCIE

Volume: 54

Issue: 66

Page Number: 9198-9201

ISSN: 1359-7345

Abstract: A water-soluble near-infrared aminocyanine dye has been developed with a long triplet-state lifetime ( = 9.16 s in deaerated ethanol). Thereby, extremely high singlet oxygen quantum yield (phi = 0.20) and low dark cytotoxicity (IC50 = 715.4 M) were achieved. The potential of the dye as a PDT photosensitizer was demonstrated.

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