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Indexed by:Journal Papers

Date of Publication:2019-12-01

Journal:JOURNAL OF COLLOID AND INTERFACE SCIENCE

Included Journals:EI、PubMed、SCIE

Volume:557

Page Number:45-54

ISSN No.:0021-9797

Key Words:Infrared photosensitizers; Photodynamic therapy; Upconversion nanoparticles; Chlorin e6; Mitochondrion-targeting

Abstract:To promote practical applications of photodynamic therapy, near-infrared (NIR) photosensitizers are manufactured based on fluorescence resonance energy transfer (FRET) between donors of anti-stoke NIR upconversion nanoparticles and acceptors of photodynamic chlorin e6. The manufactured FRET constructs displayed deep tissue penetration and FRET activation under 980 nm irradiation. Furthermore, surface decoration with mitochondria-targeting (4-marboxybutyl) triphenyl phosphonium bromide (TPP) led to mitochondrion-targeted accumulation of singlet oxygen resulting in potent cell apoptosis. Notably, in vivo anti-tumor test validates the complete ablation of intractable solid tumors based on single-dose treatment of our proposed photodynamic constructs. Therefore, the obtained results herald the tempting perspective of our carefully engineered photodynamic constructs, which could have broad utilities in clinical treatment of intractable premalignancies. (C) 2019 Elsevier Inc. All rights reserved.