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Indexed by:Journal Papers

Date of Publication:2021-04-12

Journal:ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Volume:59

Issue:45

Page Number:20008-20016

ISSN No.:1433-7851

Key Words:cisplatin; Fenton reactions; hypoxic; photodynamic therapy; synergistic

Abstract:The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O(2)(.-)produced by the PDT is converted to H(2)O(2)by superoxide dismutase, followed by the transformation of H(2)O(2)to the highly toxic(.)OH via Fenton reactions by Fe(2+)originating from the dissolution of co-loaded Fe(3)O(4)nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O(2)(.-)in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O(2)(.-)source for production of(.)OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.