Release Time:2022-04-11  Hits:

Indexed by: Journal Papers

Date of Publication: 2021-04-12

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Volume: 59

Issue: 45

Page Number: 20008-20016

ISSN: 1433-7851

Key Words: cisplatin; Fenton reactions; hypoxic; photodynamic therapy; synergistic

Abstract: The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O(2)(.-)produced by the PDT is converted to H(2)O(2)by superoxide dismutase, followed by the transformation of H(2)O(2)to the highly toxic(.)OH via Fenton reactions by Fe(2+)originating from the dissolution of co-loaded Fe(3)O(4)nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O(2)(.-)in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O(2)(.-)source for production of(.)OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.