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Indexed by:Journal Papers

Date of Publication:2021-04-12

Journal:CHEMICAL COMMUNICATIONS

Volume:55

Issue:92

Page Number:13808-13811

ISSN No.:1359-7345

Abstract:Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the "stored'' singlet oxygen on demand. The "off-on'' chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures.