Release Time:2022-04-11  Hits:

Indexed by: Journal Papers

Date of Publication: 2021-04-12

Journal: CHEMICAL COMMUNICATIONS

Volume: 55

Issue: 92

Page Number: 13808-13811

ISSN: 1359-7345

Abstract: Precise spatiotemporal control of singlet oxygen generation is of immense importance considering its involvement in photodynamic therapy. In this work, we present a rational design for an endoperoxide which is highly stable at ambient temperatures yet, can rapidly be converted into a highly labile endoperoxide, thus releasing the "stored'' singlet oxygen on demand. The "off-on'' chemical switching from the stable to the labile form is accomplished by the reaction with fluoride ions. The potential utility of controlled singlet oxygen release was demonstrated in cell cultures.