Release Time:2019-03-10  Hits:

Indexed by: Journal Article

Date of Publication: 2003-11-17

Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Included Journals: PubMed、SCIE、Scopus

Volume: 13

Issue: 22

Page Number: 3923-3926

ISSN: 0960-894X

Abstract: Telomerase inhibition can be achieved by stabilization of G-quadruplex structure. Triethylene tetraamine, a small linear molecule, has been identified as a potent telomerase inhibitor. It stabilizes both intra- and inter-molecular G-quadruplexes and shows a good differential between potent telomerase inhibition and acute cytotoxicity. (C) 2003 Elsevier Ltd. All rights reserved.