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Indexed by:期刊论文

Date of Publication:2003-11-17

Journal:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Included Journals:Scopus、SCIE、PubMed

Volume:13

Issue:22

Page Number:3923-3926

ISSN No.:0960-894X

Abstract:Telomerase inhibition can be achieved by stabilization of G-quadruplex structure. Triethylene tetraamine, a small linear molecule, has been identified as a potent telomerase inhibitor. It stabilizes both intra- and inter-molecular G-quadruplexes and shows a good differential between potent telomerase inhibition and acute cytotoxicity. (C) 2003 Elsevier Ltd. All rights reserved.