Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2013-11-11

Journal: TETRAHEDRON

Included Journals: Scopus、SCIE

Volume: 69

Issue: 45

Page Number: 9422-9427

ISSN: 0040-4020

Key Words: ortho-Nitration; Aromatic amines; Bismuth nitrate; Regioselectivity; Synthetic methods

Abstract: An efficient and one-pot synthetic method for the regioselective ortho-nitration of the N-phenyl carboxamides and primary anilines has been developed by using bismuth nitrate and acetic anhydride as the nitrating reagents. Reaction proceeds at room temperature and results in corresponding ortho-nitrated products in moderate to excellent yields. This method provides an operationally simple, regioselective, and efficient access to synthesize o-nitro anilines under the mild conditions. (C) 2013 Elsevier Ltd. All rights reserved.