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论文类型：期刊论文

发表时间：2017-07-01

发表刊物：ACS SENSORS

收录刊物：SCIE、EI、PubMed、Scopus

卷号：2

期号：7

页面范围：998-1005

ISSN号：2379-3694

关键字：Zr-based metal organic framework nanosheets; two-dimensional nanomaterials; Au nanoclusters; electrochemical aptasensor; detection of cocaine

摘要：Two-dimensional (2D) zirconium-based metal organic framework nanosheets embedded with Au nanoclusters (denoted as 2D AuNCs@521-MOF) were prepared via a one-pot method under mild conditions. The optimized 2D AuNCs@521-MOF nanosheets not only possessed high specific surface area, physicochemical stability, and good electrochemical activity but also exhibited strong bioaffinity toward biomolecule-bearing phosphate groups. Consequently, a large amount of cocaine aptamer strands can be immobilized onto the substrate modified by 2D AuNCs@521-MOF nanosheet, further leading to the formation of a constructed biosensitive platform, which can be used to successfully detect cocaine through the specific binding interactions between cocaine and aptamer strands. The results demonstrated that the 2D AuNCs@521-MOF-based aptasensor had high sensitivity for detecting cocaine within the broad concentration range of 0.001-1.0 ng.mL(-1) and the low limit of detection of 1.29 pM (0.44 pg.mL(-1)) and 2.22 pM (0.75 pg.mL(-1)) as determined by electrochemical impedance spectroscopy and differential pulse voltammetry, respectively. As expected, with the advantages of high selectivity, repeatability, stability, and simple operation, this new strategy is believed to exhibit great potential for simple and convenient detection of cocaine.