Hits:

Indexed by:期刊论文

Date of Publication:2014-05-01

Journal:JOURNAL OF FLUORINE CHEMISTRY

Included Journals:SCIE

Volume:161

Page Number:128-133

ISSN No.:0022-1139

Key Words:Trifluoromethylation; Enol acetates; Synthetic methods; alpha-CF3 ketone; Radical addition

Abstract:An efficient method for the Cu(I)-catalyzed synthesis of a-trifluoromethyl ketones via the addition of CF3 to aryl(heteroaryl) enol acetates by using the readily available CF3SO2Na (Langlois reagent) has been developed. The reaction is experimentally simple and carried out at room temperature, providing good to excellent yields with wide functional group tolerance. (C) 2014 Elsevier B.V. All rights reserved.