Ready synthesis of free N-H 2-arylindoles via the copper-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization
Release Time:2019-03-09 Hits:
Indexed by: Journal Article
Date of Publication: 2011-07-07
Journal: ORGANIC & BIOMOLECULAR CHEMISTRY
Included Journals: Scopus、PubMed、EI、SCIE
Volume: 9
Issue: 13
Page Number: 4983-4986
ISSN: 1477-0520
Abstract: A wide range of free N-H 2-arylindoles were synthesised via the copper(II)-catalyzed amination of 2-bromo-arylacetylenes with aqueous ammonia and sequential intramolecular cyclization. The convenience and atom economy of aqueous ammonia, and the low cost of the copper catalytic system make this protocol readily superior in practical application.