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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本横滨国立大学
学位：博士
所在单位：化工学院
学科：应用化学. 精细化工. 有机化学
办公地点：大连市高新区凌工路2号大连理工大学西部新区F-412
联系方式：大连市高新区凌工路2号大连理工大学西部新区F-412 邮政编码 116024 电话：0411-84986295 电子信箱：ymli@dlut.edu.cn
电子邮箱：ymli@dlut.edu.cn
A mild and fast continuous-flow trifluoromethylation of coumarins with the CF3 radical derived from CF3SO2Na and TBHP
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论文类型：期刊论文
发表时间：2015-11-28
发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY
收录刊物：SCIE、EI、PubMed、Scopus
卷号：13
期号：44
页面范围：10917-10922
ISSN号：1477-0520
摘要：A mild and fast Cu(I)-catalyzed trifluoromethylation of coumarins with CF3SO2Na and TBHP in a continuous-flow reactor has been developed. This method is experimentally simple and carried out under mild conditions, affording the corresponding products in moderate to good yields, and showing wide substrate tolerance. The scale-up flow process results in an isolated yield of 68% and a productivity of 305 mg h(-1) of 3-trifluoromethyl-7-diethylamino-4-methyl coumarin when the concentration was increased five-fold. Given these features and the widespread applications of coumarins, this method may find use from laboratory to manufacturing.