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Indexed by:期刊论文

Date of Publication:2021-01-29

Journal:CHEMICAL COMMUNICATIONS

Volume:53

Issue:48

Page Number:6448-6451

ISSN No.:1359-7345

Abstract:A 1,8-naphthalimide-derived fluorogenic probe was reported to label SNAP-tag fusion proteins in living cells. The probe can rapidly label a SNAP-tag and exhibit a fluorescence increase of 36-fold due to the additive effects of environment sensitivity of fluorophores and inhibition of photo-induced electron transfer from O-6-benzylguanine to the fluorophore. The labeling of intracellular proteins has been successfully achieved without a wash-out procedure.