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Indexed by:期刊论文

Date of Publication:2014-12-01

Journal:JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

Included Journals:SCIE

Volume:80

Issue:3-4

Page Number:383-390

ISSN No.:0923-0750

Key Words:1,8-Naphthalimide; o-N-Butylbenzene-1,2-diamine; Fluorescence; Probe; Copper ion; Live cells imaging

Abstract:A fluorescent probe LZ-N with naphthalimide as fluorophore and N-butylbenzene-1,2-diamine as a new recognition moiety for copper ion was designed and synthesized. The probe LZ-N exhibits high selectivity for Cu2+ ion in aqueous media (CH3CN:H2O = 1:1) over all the other metal ions in our study, more than 20-fold fluorescence enhancement by coordinating with Cu2+, and the maximum emission intensity independence in the range of pH 2.06-9.25. The results of H-1-NMR titration, time-resolved fluorescence decay measurement, and computational optimization illuminate the mechanisms of Cu2+ and probe LZ-N. Confocal fluorescence images and cell viability values test show the high fluorescence enhancement of probe LZ-N for exogenous Cu2+ in living cells.