Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-05-01

Journal: CHEMISTRY OF NATURAL COMPOUNDS

Included Journals: Scopus、SCIE

Volume: 48

Issue: 2

Page Number: 194-197

ISSN: 0009-3130

Key Words: alkaloid; L-alanine; transesterification; lactone

Abstract: 2-(5-Hydroxymethyl-2-formylpyrrol-1-yl)propionic acid lactone was synthesized in six steps with a 17.0% overall yield, starting from L-alanine. The synthetic route involved the Clauson-Kaas reaction, Vilsmeier reaction, and transesterification. The transesterification was the key step in the formation of the target compound.