袁文杰，博士，教授，博士生导师，生物工程学院副院长。研究方向为合成生物学与生物催化转化。致力于解析生物制造过程中微生物及酶的生理特性和催化机制，发展强化微生物生产性能的新技术和新方法，创建新一代工业菌株和酶制剂，提升生物加工过程的效率，实现生物技术产品的智造。主要研究内容包括：(1)新一代工业生产菌株改造与创制；(2)新型生物催化剂设计与催化过程创建。研究的目标集中在生物能源及生物医药产品。取得的研究结果已在Chem Eng J、Green Chem、Bioresour Technol、Fuel、J Biol Chem等国内外期刊发表论文70余篇，授权国内外专利20余项，获辽宁省科技进步奖一等奖、辽宁省自然科学成果一等奖，教育部科技进步二等奖、日内瓦专利金奖、生物工程学报优秀论文奖等多项。承担国家自然科学基金、国家重点研发项目子课题、863项目子课题、国际合作项目、企业委托项目等十余项，完成产业化项目2项。

代表性论文：

(1) Cong Du, Ying He, Jiaxin Liu, Liming Su, Yimin Li*, Wenjie Yuan*, Fengwu Bai. Metabolic coupling of acetate promotes xylose utilization in Kluyveromyces marxianus. Chemical Engineering Journal 2024,484,149762.

(2) Yimin Li, Cong Du, Zhanyu Jing, Jie Zhu, Chao Fan, Yu Jiang, and Wenjie Yuan*. Clean production of L‐Alanyl‐L‐glutamine by an efficient yeast biocatalyst expressing α‐amino acid ester ccyltransferase without N‐glycosylation. Journal of Agriculture Food Chemistry2023, 71:6398-6405.

(3) Zhanyu Jing, Jian Xu, Jia Liu, Cong Du, Jiakun Qi, Chao Fan, Yimin Li*, Wenjie Yuan*. Multiplex gene knockout raises Ala‐Gln production by Escherichia coli expressing amino acid ester acyltransferase. Applied Microbiology and Biotechnology 2023, 107:3523-3533.

(4) Cong Du, Yimin Li, Ying He, Liming Su, Huanan Wang, Wenjie Yuan* and Fengwu Bai. Fixing carbon dioxide in situ during ethanol production by formate dehydrogenase. Green Chemistry, 2022, 24, 6989

(5) Cong Du, Yimin Li, Ruijuan Xiang, Ying He, Hao Sun, Huanan Wang, Wenjie Yuan*. Co-utilization of multiple lignocellulose-derived sugars and inhibitors by the robust mutant Kluyveromyces marxianus through adaptive laboratory evolution. Fuel, 2022, 315:122816.

(6) Cong Du, Yimin Li, Han Zong, Tangguo Yuan, Wenjie Yuan^⁎, Yu Jiang. Production of bioethanol and xylitol from non-detoxified corn cob via a two-stage fermentation strategy. Bioresource Technology, 2020, 310:123427.

(7) Xuze Pei, Yimin Li, Cong Du, Tangguo Yuan, Chao Fan, Hao Hong, Wenjie Yuan*. Production of L-alanyl-L-glutamine by immobilized Escherichia coli expressing amino acid ester acyltransferase. Applied Microbiology and Biotechnology, 2020, 104: 6967-6976.

(8) Cong Du, Yimin Li, Xiaoyang Zhao, Xuze Pei, Wenjie Yuan*, Fengwu Bai, Yu Jiang. The production of ethanol from lignocellulosic biomass by Kluyveromyces marxianus CICC 1727-5 and Spathaspora passalidarum ATCC MYA-4345. Applied Microbiology and Biotechnology, 2019, 103:2845-2855.

(9) Yimin Li, Jiaoqi Gao, Xuze Pei, Cong Du, Chao Fan, Wenjie Yuan* and Fengwu Bai. Production of l alanyl l glutamine by immobilized Pichia pastoris GS115 expressingα amino acid ester acyltransferase. Microbial Cell Factories, 2019, 18:27.

(10) Wenjie Yuan, Shuguang Guo, Jiaoqi Gao, Mingming Zhong, Gonghong Yan, Wangmeng Wu, Yapeng Chao, Yu Jiang*. General control nonderepressible 2 (GCN2) kinase inhibits target of rapamycin cComplex 1 in response to amino acid starvation in Saccharomyces cerevisiae. Journal of Biological Chemistry, 2017, 292: 2660-2669.

(11) Yimin Li, Wenjie Yuan*, Jiaoqi Gao, Chao Fan, Wenzhong Wu, Fengwu Bai. Production of L-alanyl-L-glutamine by recycling E. coli expressing a-amino acid ester acyltransferase. Bioresource Technology, 2017, 245:1603-1609.

(12) Jiaoqi Gao, Hualiang Feng, Yimin Li, Shengbo Hou, Wenjie Yuan*, Shijun Zhong, Fengwu Bai. Enhanced fermentative performance under stresses of multiple lignocellulose-derived inhibitors by overexpression of a typical 2-Cys peroxiredoxin from Kluyveromyces marxianus. Biotechnol Biofuels, 2017, 10: 80-79.