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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：女
毕业院校：大连理工大学
学位：博士
所在单位：生物工程学院
学科：生物化工. 生物工程与技术. 药物工程
办公地点：生物楼512
联系方式：wangjingyun67@dlut.edu.cn
电子邮箱：wangjingyun67@dlut.edu.cn
Ratiometric Detection of Viscosity Using a Two-Photon Fluorescent Sensor
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论文类型：期刊论文
发表时间：2013-01-01
发表刊物：CHEMISTRY-A EUROPEAN JOURNAL
收录刊物：SCIE、EI、PubMed、Scopus
卷号：19
期号：5
页面范围：1548-1553
ISSN号：0947-6539
关键字：cells; fluorescence; sensors; two-photon microscopy; viscosity
摘要：In the thick of it: A carbazole-based cyanine derivative has been used as a ratiometric fluorescent sensor to detect mitochondrial viscosities over the range 1-950 cP within live cells and living tissues by using two-photon microscopy. Its success is based on the fast- and low-barrier rotation around its methine bond (see figure) and the huge increase of the fluorescence quantum yield (QY) from the loss of mobility in viscous media. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.