王静云
个人信息Personal Information
教授
博士生导师
硕士生导师
性别:女
毕业院校:大连理工大学
学位:博士
所在单位:生物工程学院
学科:生物化工. 生物工程与技术. 药物工程
办公地点:生物楼512
联系方式:wangjingyun67@dlut.edu.cn
电子邮箱:wangjingyun67@dlut.edu.cn
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Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group
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论文类型:期刊论文
发表时间:2012-12-14
发表刊物:CHEMICAL COMMUNICATIONS
收录刊物:SCIE、PubMed、Scopus
卷号:48
期号:96
页面范围:11766-11768
ISSN号:1359-7345
摘要:Rlyso, a highly selective and sensitive pH sensor, can stain lysosomes with a novel lysosome-locating group, methylcarbitol. Rlyso was successfully used to detect lysosomal pH changes during apoptosis or induced by chloroquine while avoiding the "alkalizing effect" on lysosomes of current lysosomal probes with nitrogen-containing sidechains.