Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-11-01

Journal: MEDICINAL CHEMISTRY RESEARCH

Included Journals: SCIE、Scopus

Volume: 20

Issue: 8

Page Number: 1154-1157

ISSN: 1054-2523

Key Words: Cinepazide; Vasodilator; Cis-trans isomerism; Photoisomerism

Abstract: The photoinduced tautomerisation of cinepazide maleate (1), an effective vasodilator widely used in clinical therapy, had been investigated. It was found that (i) the higher the concentration of cinepazide maleate (1), the more stable it was; (ii) the effect of light on the photoisomerism of cinepazide maleate (1) was obvious in a suitable wavelength (e.g., 365 nm); (iii) solvents (e.g., acetone) with carbonyl chromophore absorbing UV could inhibit the generation of cis-isomer; (iv) anthranilic acid could be used as an effective ultraviolet absorbent and (v) the cinepazide maleate (1) could be properly stored under the airtight, light-free and room temperature conditions.