Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-11-05

Journal: ADVANCED SYNTHESIS & CATALYSIS

Included Journals: Scopus、SCIE

Volume: 360

Issue: 21

Page Number: 4094-4098

ISSN: 1615-4150

Key Words: [1,5]-hydride shift/cyclization; benzodiazepine; tandem reaction; C(sp(3))-H functionalization; N-heterocycle

Abstract: An expedient approach to 1,4-benzodiazepines via a tandem condensation/[1,5]-hydride shift/cyclization process has been developed. This transformation started from readily available o-amino benzaldehyde and aminomalonate and was promoted by low-cost FeCl3 with high step and atom economy.