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Expedient Synthesis of 1,4-Benzodiazepines via a Tandem Condensation/[1,5]-Hydride Transfer/Cyclization Process

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Indexed by:期刊论文

Date of Publication:2018-11-05

Journal:ADVANCED SYNTHESIS & CATALYSIS

Included Journals:SCIE、Scopus

Volume:360

Issue:21

Page Number:4094-4098

ISSN No.:1615-4150

Key Words:[1,5]-hydride shift/cyclization; benzodiazepine; tandem reaction; C(sp(3))-H functionalization; N-heterocycle

Abstract:An expedient approach to 1,4-benzodiazepines via a tandem condensation/[1,5]-hydride shift/cyclization process has been developed. This transformation started from readily available o-amino benzaldehyde and aminomalonate and was promoted by low-cost FeCl3 with high step and atom economy.

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