Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-07-01

Journal: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals: SCIE

Issue: 20

Page Number: 3373-3379

ISSN: 1434-193X

Key Words: Synthetic methods; Aromatic substitution; Nitrogen heterocycles; Thiocyanates; Sulfur

Abstract: A direct C-H thiocyanation of imidazo[1,2-a]pyridines, and a practical sequential one-pot condensation/C-H thiocyanation process, using a combination of N-chlorosuccinimide/NaSCN for the synthesis of 3-thiocyanatoimidazo[1,2-a]pyridines have been developed. The reactions are environmentally friendly, and easy to carry out. They use readily available starting materials and mild reaction conditions, show a wide functional group tolerance, and give good to excellent yields.