Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-06-17

Journal: JOURNAL OF ORGANIC CHEMISTRY

Included Journals: PubMed、EI、SCIE

Volume: 81

Issue: 12

Page Number: 5202-5208

ISSN: 0022-3263

Abstract: An efficient method for the synthesis of 6-trichloromethylphenanthridines by benzoyl peroxide promoted cyclization reaction of 2-isocyanobiphenyls with carbon tetrachloride is developed. A radical pathway is proposed and evidenced for the reaction mechanism. This reaction tolerates a wide range of functional groups and the resulting 6-trichloromethylphenanthridines can be utilized as a useful synthetic precursor for corresponding 6-substituted phenanthridines.