Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-06-01

Journal: TETRAHEDRON-ASYMMETRY

Included Journals: SCIE

Volume: 27

Issue: 9-10

Page Number: 436-441

ISSN: 0957-4166

Abstract: An asymmetric fluorination process of 4-substituted pyrazolones catalyzed by quinine is revealed. The reaction afforded a wide range of 4-fluorinated pyrazol-5-ones with excellent yields (up to 98%) and moderate to good enantioselectivities (up to 81% ee). (C) 2016 Elsevier Ltd. All rights reserved.