location： Current position: Home >> Scientific Research >> Paper Publications

Prochiral alkyl-aminomethyl ketones as convenient precursors for efficient synthesis of chiral (2,3,5)-tri-substituted pyrrolidines via an organo-catalysed tandem reaction

Hits:

Indexed by:Journal Papers

Date of Publication:2016-01-01

Journal:RSC ADVANCES

Included Journals:SCIE、EI

Volume:6

Issue:61

Page Number:55764-55767

ISSN No.:2046-2069

Abstract:alpha-Aminomethyl alkyl ketones reacted smoothly with alpha, beta-unsaturated aldehydes via a tandem process catalysed by diphenylprolinol silyl ether/4-bromobenzoic acid. 2-Alkanoyl-3-aryl-5-hydroxy pyrrolidines were prepared in high yields (up to 99%) and enatioselectivities (>99% ee). The absolute configurations of the products were unambiguously confirmed by single-crystal diffraction.

Pre One:Synthesis of 6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with thiols

Next One:Ruthenium nanoparticles loaded on functionalized graphene for liquid-phase hydrogenation of fine chemicals: Comparison with carbon nanotube
Institutional Repository Personal Page

Address: No.2 Linggong Road, Ganjingzi District, Dalian City, Liaoning Province, P.R.C., 116024

Click : times
  • MOBILE Version
    •
    Open time:..
    The Last Update Time:..

    Mobile phone sweep