Release Time:2019-03-09  Hits:

Indexed by: Journal Papers

Date of Publication: 2016-01-01

Journal: RSC ADVANCES

Included Journals: EI、SCIE

Volume: 6

Issue: 61

Page Number: 55764-55767

ISSN: 2046-2069

Abstract: alpha-Aminomethyl alkyl ketones reacted smoothly with alpha, beta-unsaturated aldehydes via a tandem process catalysed by diphenylprolinol silyl ether/4-bromobenzoic acid. 2-Alkanoyl-3-aryl-5-hydroxy pyrrolidines were prepared in high yields (up to 99%) and enatioselectivities (>99% ee). The absolute configurations of the products were unambiguously confirmed by single-crystal diffraction.