Release Time:2019-03-09  Hits:

Indexed by: Journal Papers

Date of Publication: 2015-12-15

Journal: TETRAHEDRON-ASYMMETRY

Included Journals: Scopus、SCIE

Volume: 26

Issue: 23

Page Number: 1382-1387

ISSN: 0957-4166

Abstract: By employing a natural cinchona alkaloid as a catalyst, the enantioselective tandem Michael addition/oxidation of 4-substituted pyrazol-5-ones with p-benzoquinones was realized. The reaction afforded a wide range of 4,4-disubstituted pyrazol-5-ones with moderate to good yields (up to 72%) and moderate to good enantioselectivities (up to 99%). (C) 2015 Elsevier Ltd. All rights reserved.