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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本东京大学
学位：博士
所在单位：化工学院
电子邮箱：qujp@dlut.edu.cn
扫描关注
Prochiral alkyl-aminomethyl ketones as convenient precursors for efficient synthesis of chiral (2,3,5)-tri-substituted pyrrolidines via an organo-catalysed tandem reaction
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论文类型：期刊论文
发表时间：2016-01-01
发表刊物：RSC ADVANCES
收录刊物：SCIE、EI
卷号：6
期号：61
页面范围：55764-55767
ISSN号：2046-2069
摘要：alpha-Aminomethyl alkyl ketones reacted smoothly with alpha, beta-unsaturated aldehydes via a tandem process catalysed by diphenylprolinol silyl ether/4-bromobenzoic acid. 2-Alkanoyl-3-aryl-5-hydroxy pyrrolidines were prepared in high yields (up to 99%) and enatioselectivities (>99% ee). The absolute configurations of the products were unambiguously confirmed by single-crystal diffraction.