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论文类型：期刊论文

发表时间：2015-05-01

发表刊物：JOURNAL OF FLUORINE CHEMISTRY

收录刊物：SCIE

卷号：173

页面范围：6-11

ISSN号：0022-1139

关键字：Trifluoromethyl alkyl ketones; Practical synthesis; Esters; Solvent free

摘要：Trifluoromethyl ketones (TFMKs) significantly contribute to biologically active compounds and special materials. TFMKs can be prepared by "trifluoroacetic ester/ketone metathesis" along with the accompanying products, aromatic acid esters. As an important extension of our previous studies on the use of aryl alkyl ketones, wherein the separation of the resulting TFMKs and aromatic acid esters proved problematic, i-Pr and t-Bu alkyl ketones were shown in this work to be competent reaction partners for easy TFMK separation from the product mixtures, thereby providing a practical synthesis route to TFMKs. With the removal of accompanying products, i-Pr and t-Bu carboxylic esters, TFMKs with high boiling points were efficiently obtained by distillation or recrystallization. Furthermore, a solvent-free condition was also effective for this reaction, which allowed TFMKs with low boiling points to be separated from the reaction mixture by distillation in good yield. (C) 2015 Elsevier B.V. All rights reserved.