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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本东京大学
学位：博士
所在单位：化工学院
电子邮箱：qujp@dlut.edu.cn
扫描关注
Mild and Highly Enantioselective Vinylogous Aldol Reaction of Brassard's Diene with Aromatic Aldehydes by Combined Lewis Acid Catalyst
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论文类型：期刊论文
发表时间：2010-08-06
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：SCIE、EI、PubMed
卷号：75
期号：15
页面范围：5326-5329
ISSN号：0022-3263
摘要：The combined Lewis acid catalytic system, generated from (R)-1,1'-bi-2-naphthol [(R)-BINOL], Ti(O-i-Pr)(4), H2O, and lithium chloride, effectively catalyzed the enantioselective vinylogous aldol reaction of Brassard's diene with aromatic aldehydes affording the (Z)-delta-hydroxyl-alpha,beta-unsaturated esters exclusively in good yields with excellent enantioselectivities (90-99% ee) under mild conditions. A Lewis acid Lewis acid bifunctional working model was proposed for the catalytic process based on some control experiments.